血清同型半胱氨酸、叶酸、维生素B12水平与老年脑白质疏松症的相关性  

Correlation Study between Serum Homocysteine, Folate, Vitamin B12 Levels and Leukoaraiosis in Elderly Patients

作　　者：左林 赵佳[2] 姜小建[2] 袁逍 ZUO Lin;ZHAO Jia;JIANG Xiao-jian;YUAN Xiao(Department of Radiology,Tangdu Hospital of Air Force Military Medical University,Xi’an 710038,China;Department of Clinical Laboratory,Xi’an Central Hospital,Xi’an 710003,China)

机构地区：[1]空军军医大学唐都医院放射科,西安710038 [2]西安市中心医院检验科,西安710003

出　　处：《现代检验医学杂志》2019年第6期90-92,96,共4页Journal of Modern Laboratory Medicine

摘　　要：目的探讨血清同型半胱氨酸(homocysteine, HCY)、叶酸(folic acid, FA)和维生素B12(vitamin B12,Vit B12)水平与老年脑白质疏松症(leukoaraiosis,LA)的相关性。方法将2016年6月~2019年1月神经内科住院的患者111例纳入研究,检测患者血清HCY,FA和Vit B12水平。应用磁共振成像(magnetic rasonance imaging,MRI)技术,对患者行头部磁共振扫描,根据LA是否存在,分为LA组及无LA组,根据LA严重程度,分为轻度组、中度组和重度组。结果 LA组的HCY水平明显高于无LA组,LA组的FA和Vit B12水平明显低于无LA组,两组比较的差异均具有统计学意义(t=5.538,3.109,4.659,均P<0.01)。中度组和重度组的HCY水平明显高于轻度组,中度组的HCY水平明显低于重度组,差异均具有统计学意义(t=2.712~5.505,均P<0.01),轻度组的FA水平明显高于中度组及重度组,差异均具有统计学意义(t=2.238,2.099,均P<0.05),轻度组的Vit B12水平明显高于中度组及重度组,差异均具有统计学意义(t=2.433,2.966,均P<0.05)。血清HCY水平与LA程度呈正相关(r=0.344,P<0.01),血清Vit B12水平与LA程度呈负相关(r=-0.286,P<0.05)。结论 HCY,FA和Vit B12水平与LA具有密切的相关性。对老年患者行HCY, FA和Vit B12检测具有重要的临床价值。Objective To investigate the correlation between serum(homocysteine HCY), folate acid(FA), vitamin B12(Vit B12)and leukoaraiosis(LA) in elderly patients. Methods 111 patients were enrolled in the study in the department of neurology from June 2016 to January 2019. The serum levels of HCY, FA and Vit B12 were detected. Magnetic rasonance imaging(MRI) was uesd for patients with head scanning. According to whether the presence of leukoaraiosis, patients were classified as LA group and no LA group. According to the degree of LA, patients were classified as mild group, moderate group and severe group. Results The HCY levels in the LA group were significantly higher than no LA group, while the levels of FA and Vit B12 were significantly lower than no LA group, the differences were statistically significant(t=5.538, 3.109, 4.659, all P<0.01). The HCY levels in moderate group and severe group were significantly higher than mild group, and the HCY levels in severe group were significantly higher than moderate group, the differences were statistically significant(t=2.712~5.505, all P<0.01). The FA levels in moderate stenosis group and severe group were significantly lower than mild group, the differences were statistically significant(t=2.238, 2.099, all P<0.05). The Vit B12 levels in moderate group and severe group were significantly lower than mild group, the differences were statistically significant(t=2.433, 2.966, all P<0.05). The degree of LA and serum levels of HCY were positively correlated(r=0.344, P<0.01). The degree of LA and levels of Vit B12 were negatively correlated(r=-0.286, P<0.05). Conclusion The levels of HCY, FA and Vit B12 were closely related to LA. HCY, FA and Vit B12 play important roles in elderly patients.

关 键 词：脑白质疏松症 同型半胱氨酸 叶酸 维生素B12 磁共振成像 

分 类 号：R742[医药卫生—神经病学与精神病学] R446.112[医药卫生—临床医学]