SDF-1/CXCR4及下游信号通路在骨性关节炎病程中的作用  

The role of SDF-1/CXCR4 and downstream signaling pathways in the course of OA

作　　者：何映红 李彦林[1] 向耀宇 陈泳佳 杨骁[1] HE Yinghong;LI Yan?lin;XIANG Yaoyu;CHEN Yongjia;YANG Xiao(Department of Sports Medicine,the First Affiliated Hospital of Kunming Medical University,Kunming 655031,China)

机构地区：[1]昆明医科大学第一附属医院运动医学科

出　　处：《实用医学杂志》2019年第22期3563-3567,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金项目（编号：81760403）;昆明医科大学创新基金项目（编号：2019S121）

摘　　要：基质细胞衍生因子-1(stromal cell derived factor-1,SDF-1)作为一种趋化因子及其受体CXC趋化因子受体4型(chemokine receptor-4,CXCR4)在骨性关节炎(osteoarthritis,OA)的发生发展中起重要作用。SDF-1与CXCR4的结合可激活多种下游信号通路,形成复杂的信号网络,随着对有关该信号网络的深入研究,将会对骨性关节炎的发病机制有更加深入的了解,同时也会对骨性关节炎的治疗寻找到新的靶点。Stromal cell-derived factor-1(SDF-1),as a chemokine and its receptor CXC chemokine receptor type 4(CXCR4),plays an important role in the occurrence and development of OA. The combination of SDF-1 and CXCR4 activates a variety of downstream signaling pathways,involving a variety of cytokines,forming a complex signaling network. As the signal network is further studied,the etiology and mechanism of osteoarthritis will be deepened. At the same time,new therapeutic targets for osteoarthritis will be discovered.

关 键 词：基质细胞衍生因子-1 CXC趋化因子受体4 骨性关节炎 信号网络 

分 类 号：R73[医药卫生—肿瘤]