单细胞测序技术研究进展及其法医学应用展望  

Advancements in Single-cell Sequencing and the Prospect of Its Forensic Application

作　　者：陈曼 杨雅冉[1] 武会娟[3,4] 严江伟 CHEN Man;YANG Ya-ran;WU Hui-juan;YAN Jiang-wei(Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China;Beijing Center for Physical and Chemical Analysis,Beijing 100094,China;Beijing Engineering Technology Research Centre of Gene Sequencing and Gene Function Analysis,Beijing 100094,China)

机构地区：[1]中国科学院北京基因组研究所,北京100101 [2]中国科学院大学,北京100049 [3]北京市理化分析测试中心,北京100094 [4]北京市基因测序与功能分析工程技术研究中心,北京100094

出　　处：《法医学杂志》2019年第5期602-606,共5页Journal of Forensic Medicine

基　　金：国家自然科学基金资助项目(81571857);中国科学院重点部署资助项目(KGFZD-135-16-02)

摘　　要：单细胞测序是在单个细胞的水平上,利用新一代测序对DNA和RNA序列进行解析的技术。单细胞测序的超高精度给包括法医基因组在内的生命科学领域多种组学相关问题提供了新的解决思路,本文就当前该技术的研究进展和法医学应用展望进行综述。Single-cell sequencing is a technique that analyzes DNA and RNA sequences on the cellular level with next generation sequencing. The ultra high resolution of single-cell sequencing provides new perspectives and opens new frontiers for our understanding of many areas of life sciences, including forensic genome. This paper summarizes the recent advancements in single-cell sequencing and the prospect of its forensic application.

关 键 词：法医遗传学 单细胞测序 基因组 综述 

分 类 号：DF795.2[医药卫生—法医学]