核受体家族在炎症性肠病中的作用机制  

Mechanism of Nuclear Receptors in Inflammatory Bowel Disease

作　　者：董月美 张方 赵美华[1] 张目涵 冯百岁[1] DONG Yuemei;ZHANG Fang;ZHAO Meihua;ZHANG Muhan;FENG Baisui(Department of Gastroenterology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)

机构地区：[1]郑州大学第二附属医院消化内科,郑州450014

出　　处：《医学综述》2019年第22期4369-4373,共5页Medical Recapitulate

基　　金：国家自然科学基金(81070288,81270452);河南省卫生计生科技创新型人才特聘学科带头人;河南省自然科学基金(162300410268);河南省医学科技攻关计划项目(201502015)。

摘　　要：炎症性肠病(IBD)是一组主要累及结直肠的慢性特发性疾病,具体发病机制尚不明确,可能涉及肠道微生物群失调、上皮细胞破坏、异常黏膜免疫反应和基因易感性等多种因素。核受体在消化系统稳态中发挥着至关重要的作用,如调节肠道微生物群、参与胆汁酸肠-肝循环过程、吸收或分泌溶质和水分以及营养物质运输等过程,部分核受体成员还参与调控肠道免疫反应、维持肠道上皮细胞及黏膜屏障完整性,并与IBD的病理生理过程关系密切。Inflammatory bowel disease(IBD)is a group of chronic idiopathic diseases that mainly involves the colorectum.The pathogenesis of IBD is still unclear,and may involve various factors such as intestinal microflora dysregulation,epithelial destruction,abnormal mucosal immune response,and genetic susceptibility.Nuclear receptors play a vital role in gastrointestinal wall,such as changing gut microbiota,regulating bile acid homeostasis,absorbing/secreting solute and water,and transporting nutrients.Some nuclear receptors are also involved in regulating the intestinal immune response,maintaining the integrity of intestinal epithelial cells and mucosal barrier,and are closely related to the pathophysiological processes of IBD.

关 键 词：炎症性肠病 核受体 过氧化物酶体增殖物激活受体Γ 孕烷X受体 法尼醇X受体 维甲酸相关孤儿受体γ 维生素D受体 

分 类 号：R574[医药卫生—消化系统]