N^6-甲基腺苷及其调控蛋白在肿瘤中的研究进展  

Research Progress of N^6-Methyladenosine and Its Regulatory Proteins on Tumors

作　　者：谷仕艳 李萌竹 何作顺 GU Shiyan;LI Mengzhu;HE Zuoshun(Faculty of Public Health,Dali University,Dali 671000,China)

机构地区：[1]大理大学公共卫生学院

出　　处：《医学综述》2019年第22期4412-4416,4426,共5页Medical Recapitulate

基　　金：中国西南药用昆虫及蛛形类资源开发利用协同创新中心开放课题(CIC1802);大理大学博士科研启动基金项目(KYBS2018006)

摘　　要：N^6-甲基腺苷(m^6A)是最常见的真核生物RNA甲基化修饰,由甲基转移酶、去甲基化酶和甲基结合蛋白等共同催化调控。m^6A及其甲基转移酶、去甲基化酶和甲基结合蛋白在肺癌、肝癌、胃癌、乳腺癌等多种实体肿瘤及血液肿瘤的发生发展中均有重要的调控作用,且m^6A及其调控蛋白水平的异常还与部分肿瘤患者的预后和药物治疗效果密切相关。深入研究m^6A及其甲基转移酶、去甲基化酶和甲基结合蛋白在不同肿瘤中的作用和机制,可为肿瘤的预防、诊断和治疗提供参考。N^6-methyladenosine(m^6A)is the most common eukaryotic RNA methylation modification,which is regulated by methyltransferases,demethylases and methyl-binding proteins.m^6A and its methyltransferase,demethylase and methyl-binding proteins play important regulatory roles in the occurrence and development of lung cancer,liver cancer,gastric cancer,breast cancer and other solid tumors and hematological tumors,and the abnormalities of m^6A and its regulatory protein levels are closely related to the prognosis and drug treatment effect of some tumor patients.Further study on the roles and mechanisms of m 6A and its methyltransferases,demethylases and methyl-binding proteins in different tumors can provide references for the prevention,diagnosis and treatment of tumors.

关 键 词：肿瘤 N^6-甲基腺苷 调控蛋白 甲基转移酶 去甲基化酶 甲基结合蛋白 

分 类 号：R730[医药卫生—肿瘤]