原发性胃肠道非霍奇金淋巴瘤的临床特征及预后因素效果观察  

Clinical characteristics and prognostic factors of primary gastrointestinal non-Hodgkin’s lymphoma

作　　者：谷敏 柴晓艳 沈涵菁 田亚丽 Gu Min;Chai Xiaoyan;Shen Hanjing;Tian Yali(Department of Oncology,Suzhou Science and Technology Hospital,Suzhou,Jiangsu,215000,China)

机构地区：[1]苏州科技城医院肿瘤血液科

出　　处：《当代医学》2019年第34期66-68,共3页Contemporary Medicine

基　　金：2018年度苏州高新区医疗卫生科技计划项目（2018z006)

摘　　要：目的研究原发性胃肠道非霍奇金淋巴瘤的临床特征及预后因素效果。方法选择2008年1月至2013年6月在苏州大学附属第一医院接受治疗的30例原发性胃肠道非霍奇金淋巴瘤患者作为本研究对象,对其临床特征及预后因素进行分析。结果原发性胃肠道非霍奇金淋巴瘤患者的临床表现以非特异性为主,本组30例患者中,主要临床表现为贫血、缺乏食欲、腹痛,占比分别为53.33%、46.67%、73.33%。并发症包括1例消化道穿孔、2例消化道出血、4例消化道梗阻。所有患者均进行胶囊内镜检查或胃肠镜检查,在初次胃镜检查中,有9例患者诊断为原发性胃肠道非霍奇金淋巴瘤,其中13例误诊为低分化或中等分化胃癌、误诊5例为良性胃溃疡、有3例被误诊为胃间质瘤。随访平均时间(45.34±1.09)个月,5年生存率为46.67%。经多因素Cox分析显示,影响患者生存时间的不良指标包括临床分期和肿瘤大小,而肿瘤类型、治疗方式、肿瘤部位与患者生存时间无明显相关性。结论影响原发性胃肠道非霍奇金淋巴瘤预后的因素较多,比如临床分期、肿瘤大小等,临床应以化疗或化疗联合放疗方式进行治疗,从而改善患者预后。Objective To study clinical features and prognostic factors of primary gastrointestinal non-Hodgkin’ s lymphoma. Methods Thirty patients with primary gastrointestinal non-Hodgkin’s lymphoma who were treated at the First Affiliated Hospital of Soochow University from January 2008 to June 2013 were selected as subjects for their clinical features and prognosis factor analysis. Results The clinical manifestations of patients with primary gastrointestinal non-Hodgkin’s lymphoma were non-specific. The main clinical manifestations of this group were anemia, lack of appetite and abdominal pain, the proportion was 53.33%, 46.67% and 73.33% respectively. Complications included 1 case of digestive tract perforation, 2 cases of gastrointestinal bleeding, and 4 cases of digestive tract obstruction. All patients underwent capsule endoscopy or gastrointestinal endoscopy. In the initial gastroscopy, 9 patients were diagnosed with primary gastrointestinal non-Hodgkin’ s lymphoma, 13 of which were misdiagnosed as poorly or moderately differentiated gastric cancer. 5 cases were misdiagnosed as benign gastric ulcer, and 3 cases were misdiagnosed as gastric stromal tumor. The mean follow-up time was(45.34±1.09) months, and the 5-year survival rate was 46.67%. Multivariate Cox analysis showed that the adverse indicators affecting the survival time of patients included clinical stage and tumor size, but there was no significant correlation between tumor type, treatment mode, tumor location and patient survival time. Conclusion There are many factors affecting the prognosis of primary gastrointestinal non-Hodgkin’ s lymphoma, such as clinical stage, tumor size, etc. Clinically, chemotherapy or chemotherapy combined with radiotherapy should be used to improve the prognosis of patients.

关 键 词：原发性胃肠道非霍奇金淋巴瘤 临床特征 预后因素 效果 

分 类 号：R73[医药卫生—肿瘤]