Effects of pore size and porosity of surface-modified porous titanium implants on bone tissue ingrowth  

表面改性多孔钛植入体孔径和孔隙率对骨长入的影响（英文）

作　　者：Jing-pu ZHENG Liang-jian CHEN Dai-yuan CHEN Chun-sheng SHAO Man-fei YI Bo ZHANG 郑景璞;陈良建;陈代远;邵春生;易曼菲;张博(中南大学湘雅三医院口腔科,长沙410013;中南大学粉末冶金国家重点实验室,长沙410083)

机构地区：[1]Department of Stomatology,Third Xiangya Hospital,Central South University,Changsha 410013,China [2]State Key Laboratory of Powder Metallurgy,Central South University,Changsha 410083,China

出　　处：《Transactions of Nonferrous Metals Society of China》2019年第12期2534-2545,共12页中国有色金属学报（英文版）

基　　金：Project(81571021) supported by the National Natural Science Foundation of China;Projects(2015WK3012,2018SK2017) supported by the Hunan Provincial Science and Technology Department Project,China;Project(20160301) supported by New Talent Project of the Third Xiangya Hospital of Central South University,China

摘　　要：The effects of surface-modified porous titanium implants with different porosities and pore sizes on osseointegration were investigated in vivo.Three porous titanium implants(A30,A40 and A50 containing volume fractions of space-holder NaCl being 30%,40%and 50%,respectively)were manufactured by metal injection moulding(MIM).The surface-modified implants were implanted into muscles and femurs of hybrid male dogs.Interface osteogenic activity and histological bone ingrowth of porous titanium implants were evaluated at 28,56 and 84 d.The results showed that when additive space-holder amount of NaCl increased from 30%to 50%(volume fraction),the general porosity and mass fraction of macropores of porous titanium rose from 42.4%to 62.0%and from 8.3%to 69.3%,respectively.Histologic sections and fluorescent labeling showed that the A50 implant demonstrated a significantly higher osteogenic capacity at 28 d than other implants.Bone ingrowth into the A30 implant was lower than that into other implants at 84 d.Therefore,the pore structure of A50 implant was suitable for new bone tissue to grow into porous implant.研究表面改性多孔钛种植体孔隙率和孔径对骨整合的影响。用粉末注射成形技术制备3种多孔钛植入体(A30,A40和A50,造孔剂NaCl的体积分数分别为30%,40%和50%)。将改性后的多孔植入体分别植入狗的背部肌肉和股骨内28、56和84 d后,检测多孔钛植入体与宿主骨之间界面成骨活性和骨组织长入孔隙内的情况。结果表明,喂料中造孔剂NaCl的添加量从30%增至50%(体积分数),多孔钛的总孔隙率从42.4%增至62.0%,大孔径(>50μm)多孔钛的质量分数从8.3%增至69.3%。组织学和荧光标记结果显示,A50植入体在28 d时骨界面的成骨活性明显高于其他组,在84d时A30植入体骨长入的量低于其他组。因此,A50植入体的孔结构适合新骨组织长入多孔植入体。

关 键 词：porous titanium implant POROSITY aperture INTERCONNECTIVITY OSSEOINTEGRATION 

分 类 号：R78[医药卫生—口腔医学]