“肠-肝轴”对非酒精性脂肪性肝病的影响  

Effect of “intestinal-hepatic axis” on non-alcoholic fatty liver disease

作　　者：孙智强 李京涛 魏海梁 闫曙光[1] 李日向 郭英君[3] 常占杰 SUN Zhiqiang;LI Jingtao;WEI Hailiang;YAN Shuguang;LI Rixiang;GUO Yingjun;CHANG Zhanjie(Shaanxi University of Chinese Medicine,Xianyang 712046;Department of Hepatology,Afiliated Hospital of Shaanxi University of Chinese Medicine;Department of Infections Disease,People’s Hospital of Ningxia Hui Autonomous Region,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学附属医院肝病一科 [3]宁夏回族自治区人民医院感染科

出　　处：《胃肠病学和肝病学杂志》2019年第11期1312-1315,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金(81603612);陕西省科技厅科研基金(2016SF-234、2018KJXX-093);陕西省教育厅基金(16JK1212);陕西中医药大学学科创新团队建设项目(2019-YL05)

摘　　要：肠道与肝脏通过“肠-肝轴”紧密连接,肠黏膜通透性增加、内毒素血症和肠道微生物的改变等均可促进肝脏疾病的发生、发展。本文着重讨论“肠-肝轴”如何影响非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的发生、发展,为NAFLD的防治和研究提供新思路。The intestinal tract and the liver are tightly connected by the“intestinal-hepatic axis”,and the increase of intestinal mucosal permeability,endotoxemia and intestinal microbial changes can promote the development of liver diseases.This article focused on how the“intestinal-hepatic axis”affects the development of non-alcoholic fatty liver disease(NAFLD)and provided new ideas for the prevention and treatment of NAFLD.

关 键 词：肠-肝轴 非酒精性脂肪性肝病 肠黏膜屏障 内毒素 肠道微生态 

分 类 号：R57[医药卫生—消化系统]