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作 者:陈玉乐[1] 杨文杰 吕伟 刘天杰 李磊[1] CHEN Yu-le;YANG Wen-jie;L Wei;LIU Tian-jie;LI Lei(Department of Urology,First Affiliated Hospital of Xi an Jiaotong University,Xi an 710061,China)
机构地区:[1]西安交通大学第一附属医院泌尿外科
出 处:《现代泌尿外科杂志》2019年第12期1038-1041,共4页Journal of Modern Urology
基 金:国家自然科学基金项目(No.81872093)
摘 要:目的探讨肾上腺髓质素(AM)及其受体调节蛋白RAMP2和RAMP3在膀胱癌中的表达和意义。方法采用免疫组织化学染色检测58例人膀胱癌组织和25例癌旁尿路上皮组织中AM、RAMP2、RAMP3的表达,分析AM、RAMP2、RAMP3在膀胱癌及癌旁尿路上皮组织的表达差异以及与临床病理特征之间的关系。结果 AM在膀胱癌细胞与间质细胞均有明显表达。AM和RAMP3在膀胱癌组织和癌旁尿路上皮组织间表达无明显差异(39.6%vs.44%、82.8%vs.76%),且在癌组织中的表达与病理分级、临床分期及患者预后等无明显相关性。RAMP2在膀胱癌组织的表达明显强于癌旁尿路上皮组织(55.2%vs.28%)。RAMP2+的膀胱癌患者较RAMP2-的患者具有更短的总生存期(HR:2.73,95%CI:1.30~5.80,P<0.01)。结论膀胱癌微环境中的AM可来源于肿瘤细胞和间质细胞。RAMP2在膀胱癌组织表达上调,是膀胱癌中AM下游信号的关键调节蛋白及患者预后指标。Objective To determine the expressions and significance of adrenomedullin(AM)and its key receptor accessory proteins,RAMP2 and RAMP3 in bladder cancer.Methods Expressions of AM,RAMP2 and RAMP3 in 58 bladder cancer tissues and 25 adjacent urothelial tissues were evaluated with immunohistochemistry staining.Association between AM,RAMP2 and RAMP3 expressions and the clinicopathologic features such as grade,stage and patients’survival was analyzed.Results AM was widely expressed in both bladder cancer and stromal components.There was no significant difference in AM and RAMP3 expressions between adjacent urothelial tissues and bladder cancer tissues(39.6% vs.44%,82.8% vs.76%,respectively).RAMP2 was overexpressed in bladder cancer tissues compared with adjacent urothelial tissues(55.2% vs.28%).There was no association between AM and RAMP3 expressions and pathological grading,clinical stage and patients’prognosis.RAMP2 was associated with short overall survival(HR 2.73,95%CI:1.30-5.80,P<0.01).Conclusion AM in tumor microenvironment of bladder cancer was originated from both cancer cells and stromal cells.RAMP2 was overexpressed in bladder cancer and might act as a prognostic marker and key regulator of AM signaling.
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