白芨/聚乳酸血复合膜的制备及性能测试  

Preparation and performance test of Bletilla striata/polylactic acid (PLA) hemostatic composite membrane

作　　者：巩桂芬[1] 曹景飞 徐阿文 荀阳舰 GONG Guifen;CAO Jingfei;XU Awen;XUN Yangjian(School of Materials Science and Engineering,Harbin University of Science and Technology,Harbin,Heilongjiang 150040,China)

机构地区：[1]哈尔滨理工大学材料科学与工程学院

出　　处：《江苏大学学报（自然科学版）》2020年第1期46-50,共5页Journal of Jiangsu University：Natural Science Edition

基　　金：国家自然科学基金资助项目(51603075)

摘　　要：以可降解的聚乳酸(PLA)为基体,利用高压静电纺丝技术制备成具有三维网状结构的多孔纤维膜,然后以不同质量分数的白芨胶为浸渍液,用超声和热压的方法制备一种以聚乳酸为纳米骨架的白芨多糖止血复合膜.采用扫描电子显微镜(SEM)、傅里叶变换红外光谱仪(FTIR)、万能拉伸试验机、热重分析仪(TGA)对复合膜进行了表征测试,并对其进行了组织创口止血性能和愈合性能测试.结果表明:白芨多糖充分填充了复合膜的三维孔隙,复合膜拉伸强度最高为9.512 MPa,80℃以下能够稳定存在;复合膜有良好的止血功能,与生理盐水对照组相比止血时间平均减少了60%,且止血生肌效果明显.With the degradable polylactic acid(PLA)as matrix,the porous membrane with three-dimensional reticular structure was prepared by high-voltage electrostatic spinning technology.Using different concentration Bletilla striata as impregnation solution,Bletilla striata polysaccharide hemostatic composite membrane with polylactic acid(PLA)as nano-skeleton was prepared by ultrasonic and hot pressing.The composite membrane was characterized by scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FTIR),universal tensile testing machine and thermogravimetric analyzer(TGA).The hemostatic properties and healing properties of tissue wounds were tested.The results show that the Bletilla striata polysaccharide are fully filled in the three-dimensional pores of the composite membrane.The tensile strength of the composite membrane is up to 9.512 MPa,which can be stably existed below 80℃.Compared with the saline control group,the composite membrane has good hemostatic function and obvious hemostasis effect,and the hemostasis time is reduced by 60%.

关 键 词：白芨 聚乳酸 高压静电纺丝 复合膜 止血生肌 

分 类 号：TB332[一般工业技术—材料科学与工程] TQ340.64[化学工程—化纤工业]