Fluorescent Supramolecular Polymersomes Based on Pillararene/Paraquat Molecular Recognition for pH-controlled Drug Release  

作　　者：Run Zhao Yu-Juan Zhou Ke-Cheng Jie Jie Yang Sebastien Perrier Fei-He Huang 

机构地区：[1]State Key Laboratory of Chemical Engineering,Center for Chemistry of High-Performance&Novel Materials,Department of Chemistry,Zhejiang University,Hangzhou 310027,China [2]Department of Chemistry,The University of Warwick,Coventry CV47AL,UK [3]Faculty of Pharmacy and Pharmaceutical Sciences,Monash University,381 Royal Parade,Parkville,VIC3052,Australia [4]Warwick Medical School,The University of Warwick,Coventry GV47AL,UK

出　　处：《Chinese Journal of Polymer Science》2020年第1期1-8,I0004,共9页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (No. 21861130352);Newton Advanced Fellowships of The Royal Society (No. NAF\R10066)

摘　　要：Researchers have put significant efforts on developing versatile fluorescent polymeric systems due to their promising biological/biomedical labelling, tracking, monitoring, imaging, and diagnostic applications. However, complicated organic/polymeric synthesis or post-modification of these functionalized platforms is still a big obstacle for their further application and thereby provides clear motivation for exploring alternative strategies for the design and fabrication of easily available fluorescent systems. The marriage of supramolecular polymers and fluorescent imaging can provide a facile and dynamic manner instead of tedious and time-consuming synthesis due to the dynamic and reversible nature of noncovalent interactions. Herein, based on water-soluble pillararene/paraquat molecular recognition, we successfully prepare two amphiphilic polypseudorotaxanes which can self-assemble into supramolecular polymersomes in water. These polymersomes can be reversibly destroyed and reformed by tuning the solution p H. Attributed to the aggregation-induced emission of tetraphenylethylene groups,intense fluorescence can be introduced into the obtained supramolecular polymersomes. Furthermore, p H-triggered release of an encapsulated water-insoluble drug(doxorubicin) from the self-assembled fluorescent supramolecular polymersomes is also investigated.Researchers have put significant efforts on developing versatile fluorescent polymeric systems due to their promising biological/biomedical labelling, tracking, monitoring, imaging, and diagnostic applications. However, complicated organic/polymeric synthesis or post-modification of these functionalized platforms is still a big obstacle for their further application and thereby provides clear motivation for exploring alternative strategies for the design and fabrication of easily available fluorescent systems. The marriage of supramolecular polymers and fluorescent imaging can provide a facile and dynamic manner instead of tedious and time-consuming synthesis due to the dynamic and reversible nature of noncovalent interactions. Herein, based on water-soluble pillararene/paraquat molecular recognition, we successfully prepare two amphiphilic polypseudorotaxanes which can self-assemble into supramolecular polymersomes in water. These polymersomes can be reversibly destroyed and reformed by tuning the solution p H. Attributed to the aggregation-induced emission of tetraphenylethylene groups,intense fluorescence can be introduced into the obtained supramolecular polymersomes. Furthermore, p H-triggered release of an encapsulated water-insoluble drug(doxorubicin) from the self-assembled fluorescent supramolecular polymersomes is also investigated.

关 键 词：Fluorescent polymers Aggregation-induced emission Host-guest interactions RESPONSIVENESS 

分 类 号：TQ317[化学工程—高聚物工业] TQ460.1