康柏西普联合不同手术治疗新生血管性青光眼的临床观察  

Clinical study of Conbercept combined with surgery in the treatment of neovascular glaucoma

作　　者：张茸[1] 邹吉新[1] 赵丽君[1] 刘升强[2] ZHANG Rong;ZOU Jixin;ZHAO Lijun;LIU Shengqiang(Department of Ophthalmology,the Third People's Hospital of Dalian,Dalian 116033,China;Department of Ophthalmology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China)

机构地区：[1]大连市第三人民医院眼科,辽宁大连116033 [2]大连医科大学附属第二医院眼科,辽宁大连116027

出　　处：《大连医科大学学报》2019年第6期525-529,共5页Journal of Dalian Medical University

摘　　要：目的探讨玻璃体腔注射康柏西普联合FP-7Ahmed青光眼引流阀植入与康柏西普联合小梁切除术治疗新生血管性青光眼的临床疗效差异。方法回顾性分析大连市第三人民医院2014年1月至2015年1月收治的70例70眼新生血管性青光眼患者的临床资料。根据患者所接受的治疗方法分为康柏西普联合FP-7Ahmed引流阀植入术组(A组)36例36眼和康柏西普联合小梁切除组(B组)34例34眼,术前3天行玻璃体腔注射康柏西普(0.05 mL/0.5 mg),待药物起效后分别行两种术式治疗,术后不同时间段随访1年,分别对两组术后眼压、视力、并发症及手术成功率进行比较。结果两组患者术后视力提高率比较差异有统计学意义(P<0.05),A组术后视力提高率明显高于B组。两组患者术后眼压均较术前明显下降,差异有统计学意义(P<0.01),两组患者术后1周、1个月、3个月及6个月眼压比较,差异均无统计学意义(P>0.05),但术后1年A组的术后平均眼压明显低于B组(P<0.05)。两组患者术后并发症的发生率比较差异无统计学意义(P>0.05),两组患者绝对手术成功率无明显差异(P>0.05),但相对手术成功率及失败率两组间比较,A组明显优于B组(P<0.05)。结论康柏西普联合FP-7Ahmed青光眼引流阀植入术和康柏西普联合小梁切除术治疗新生血管性青光眼均可有效控制眼压,前者对远期的眼压控制及视功能的稳定性更为持久。Objective To investigate the clinical efficacy of intravitreal injection of Conbercept combined with different surgical approaches in the treatment of neovascular glaucoma. Methods The clinical data of 70 patients with neovascular glaucoma, who were admitted to The Third People’s Hospital of Dalian from January 2014 to January 2015, were retrospectively analyzed. According to the treatment method, the patients were divided into Conbercept combined with FP-7 Ahmed glaucoma valve implantation group(Group A)including 36 patients(36 eyes) and Conbercept combined with trabeculectomy group(Group B)including 34 patients(34 eyes). Conbercept(0.05 mL/0.5 mg) was injected into vitreous cavity 3-7 days before surgery, and then two different surgical treatments were performed after iris neovascularization regression. The patients were followed up for 1 year at different time after surgery. Intraocular pressure, vision and complications were observed in the two groups and success rate of operation was compared. Results The visual acuity improved postoperatively. The visual acuity improvement rate in group A was significantly higher than that in group B(P<0.05). The postoperative intraocular pressure in both groups were significantly lower compared to the preoperative measurements(P<0.01). There was no significant difference in the intraocular pressure between the two groups in 1 week, 1 month, 3 months and 6 months after surgery(P<0.05). However, the average intraocular pressure at 1-year follow-up in group A was significantly lower than that in group B(P<0.05). There was no significant difference in the incidence of postoperative complications between the two groups(P>0.05). There was no significant difference in the absolute surgical success rate between the two groups(P>0.05). However, in the comparison of the relative success rate and failure rate between the two groups, the A group was significantly better than the B group(P<0.05). Conclusion Conbercept combined with FP-7 Ahmed glaucoma valve implantation and Conbercep

关 键 词：康柏西普 引流阀 新生血管性青光眼 小梁切除术 

分 类 号：R775[医药卫生—眼科]