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作 者:赵华新 邵晓雁[1,2,3,4] 郭献灵 许青 ZHAO Huaxin;SHAO Xiaoyan;GUO Xianling;XU Qing(Department of Oncology,Shanghai Dermatology Hospital,Shanghai 200443,China;Department of Oncology,Shanghai Tenth People's Hospital,Tongji University,Shanghai 200072,China;Tongji University Cancer Center,Shanghai 200072,China;Department of Oncology,Xuzhou Center Hospital,Xuzhou 221009,China)
机构地区:[1]上海皮肤病医院肿瘤科,上海200443 [2]同济大学附属第十人民医院肿瘤科,上海200072 [3]同济大学癌症中心,上海200072 [4]徐州市中心医院肿瘤科,江苏徐州221009
出 处:《医学综述》2019年第24期4860-4865,4871,共7页Medical Recapitulate
基 金:国家自然科学基金面上项目(81772905)
摘 要:恶性黑色素瘤是一种侵袭性极高的恶性肿瘤,在肿瘤早期阶段便可发生转移,晚期患者预后极差,且发病率和病死率逐年攀升。皮肤黑色素瘤是全球最常见的黑色素瘤类型,但肢端和黏膜型黑色素瘤是我国较常见的黑色素瘤亚型,诊断时大多患者已处于肿瘤晚期,药物疗效及预后均较皮肤恶性黑色素瘤差。近年来,免疫治疗在黑色素瘤治疗中取得了较大进展,其中,免疫检查点抑制剂取得了较好的疗效,而溶瘤病毒的治疗为患者提供了更多的治疗机会。Malignant melanoma is a highly aggressive malignant tumor that can metastasize in the early stages of tumorigenesis.The prognosis of patients at advanced stage is extremely poor.And the morbidity and mortality rate have been increasing year by year.Skin melanoma is the most common type of melanoma in the world,while acral and mucosal melanoma are common subtypes in China,and at the time of diagnosis,most of the patients are in the advanced stage expecting poorer drug treatment effect and prognosis than those of the skin malignant melanoma.In recent years,immunotherapy has made great progress in the treatment of melanoma.Among them,immune checkpoint inhibitors have achieved good results,and oncolytic virus treatment has provided the patients with more treatment opportunities.
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