发作性偏头痛与慢性偏头痛病人中医证型分布及其对外周血CGRP、SP水平的影响  

Distribution of Traditional Chinese Medicine Syndromes in Episodic Migraine and Chronic Migraine and Correlation with CGRP and SP Levels in Peripheral Blood

作　　者：陈励竞 CHEN Lijing(Shijiazhuang Traditional Chinese Medical Hospital,Shijiazhuang 050051,Hebei,China)

机构地区：[1]石家庄市中医院

出　　处：《中西医结合心脑血管病杂志》2019年第23期3694-3697,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：河北省中医药管理局课题(No.2016089)

摘　　要：目的了解发作性偏头痛(EM)与慢性偏头痛(CM)病人的中医证型分布特点及其不同中医证型对外周血降钙素基因相关肽(CGRP)、P物质(SP)水平的影响。方法选择102例偏头痛病人作为病例组,其中发作性偏头痛病人(EM组)52例,慢性偏头痛病人(CM组)50例;选择50名正常体检者为对照组(NC组)。检测3组的CGRP、SP水平,比较组间差异性。分析EM组和CM组病人中医证候分布差异及不同证型病人外周血CGRP、SP水平的差异。结果CM组发作间期的CGRP、SP水平明显高于EM组发作间期的水平,且两组均高于正常对照组,差异均有统计学意义(P<0.05)。中医证型分布比较,CM组瘀血阻络证、肝阳上亢证出现率明显高于EM组,痰浊内阻证出现率明显低于EM组,差异均有统计学意义(P<0.05)。两组中医证型与CGRP、SP水平分析,瘀血阻络证、肝阳上亢证病人外周血CGRP、SP水平明显高于其余各证型病人,差异有统计学意义(P<0.05)。结论外周血CGRP、SP水平升高可能是EM进展为CM的重要标志。Objective To analyse the differences in the distribution of traditional Chinese medicine(TCM)syndromes between episodic migraine(EM)and chronic migraine(CM),and the correlation between TCM syndromes and levels of calcitonin gene-related peptide(CGRP)and substance P(SP)in peripheral blood.Methods One hundred and two patients with migraine were selected as the case group,of which 52 cases were EM patients(EM group)and 50 cases were CM patients(CM group).Fifty normal physical examination subjects were selected as control group(NC group).The CGRP and SP levels of three groups were detected and compared.The distribution of TCM symptoms,and the CGRP and SP levels in peripheral blood between patients with EM and CM were analyzed.Results The levels of CGRP and SP during intermittent periods were significantly higher in the CM group than those in the EM group,which were higher in two groups than the normal control group(P<0.05).Comparing the distribution of TCM syndrome types,the incidence of blood stasis syndrome and liver-yang hyperactivity syndrome in the CM group was significantly higher than that in the EM group.The incidence of phlegm syndrome was significantly lower in the CM group than that in the EM group,and the differences were statistically significant(P<0.05).The levels of CGRP and SP in peripheral blood in patients with blood stasis syndrome and liver-yang hyperactivity syndrome were significantly higher than those in patients with other syndrome types,the difference was statistically significant(P<0.05).Conclusion The elevated levels of CGRP and SP in peripheral blood may be an important indicator of the progression of EM to CM,which provide a basis for the clinical diagnosis and treatment of EM and CM.

关 键 词：发作性偏头痛 慢性偏头痛 中医证型 降钙素基因相关肽 P物质 

分 类 号：R747.2[医药卫生—神经病学与精神病学] R255.2[医药卫生—临床医学]