益生菌抗衰老作用机制研究进展  

Anti-aging Effect and Molecular Mechanism of Probiotics:A Review

作　　者：余洁 刘昕 张驰 赵吉春 李富华[1,2] 明建[1,2] YU Jie;LIU Xin;ZHANG Chi;ZHAO Ji-chun;LI Fu-hua;MING Jian(College of Food Science,Southwest University,Chongqing 400715;Research Center of Food Storage&Logistics,Southwest University,Chongqing 400715)

机构地区：[1]西南大学食品科学学院,重庆400715 [2]西南大学食品贮藏与物流研究中心,重庆400715

出　　处：《生物技术通报》2020年第1期167-174,共8页Biotechnology Bulletin

基　　金：西南大学博士启动基金项目(SWU118095)

摘　　要：衰老会引起机体诸多不良的生理变化并增加对疾病的易感性,明确引发衰老的机制对于寻找其干预措施至关重要。研究发现,自由基氧化应激、炎症性衰老、免疫衰老、肠道菌群失调是引发衰老的相关机制。益生菌被报道具有潜在的延缓衰老作用,比较分析了常用益生菌抗衰老评价模型,并从衰老引发机制出发,重点综述了益生菌对肠道菌群的调节机制和抗衰老相关信号通路的影响,旨为进一步研究益生菌抗衰老作用提供新思路。Aging can cause many adverse physiological changes in individuals and increase their susceptibility to disease.Clasrifying the mechanism of aging is crucial for seeking intervention approaches.Current research findings suggest that free radical oxidative stress,inflammatory aging,immune aging,and intestinal flora imbalance are the main mechanisms of aging.Besides,probiotics have been reported to have potential anti-aging effects.This paper compares and analyzes the anti-aging evaluation models of probiotics,and focuses on the effects of probiotics on senescence-induced alterations of intestinal flora and anti-aging related signaling pathways,thus providing new ideas for further studying the anti-aging effect of probiotics.

关 键 词：益生菌 抗衰老 评价模型 

分 类 号：R28[医药卫生—中药学]