唾液生物标志物在口腔癌筛查中的应用  

Application of saliva biomarkers in oral cancer screening

作　　者：黄璐 戴杰 吴燕岷[1] Huang Lu;Dai Jie;Wu Yanmin(Dept.of Oral Medicine,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;Dept.of Stomatology,The Dajiangdong Hospital,Hangzhou 311225,China;Dept.of Stomatology,Luqiao Hospital District,Taizhou Hospital,Taizhou 318050,China)

机构地区：[1]浙江大学医学院附属第二医院口腔内科,杭州310009 [2]杭州市大江东医院口腔科,杭州311225 [3]台州医院路桥院区口腔科,台州318050

出　　处：《国际口腔医学杂志》2020年第1期68-75,共8页International Journal of Stomatology

基　　金：浙江省科技厅公益研究计划(LGF18H140003)~~

摘　　要：唾液含有丰富的DNA、RNA、蛋白质、微生物及代谢产物。它作为一种无创、安全的来源,可以替代血液用于疾病的诊断和预后。随着微阵列技术、全基因组测序、全转录组测序等高通量技术的快速发展,研究发现唾液是一个潜在的巨大生物标志物储存库,已有多种疾病特异性唾液标志物被挖掘。本文整合了已报道的有关口腔癌及癌前筛查的唾液生物标志物,探讨了唾液作为该领域生物标志物的优缺点及改进策略,以期为将来口腔癌的早期诊断及治疗提供参考。Saliva secreted by salivary glands is rich in DNA,RNA,proteins,microorganisms and metabolites.As a noninvasive and safe source,saliva can replace blood in the diagnosis and prognosis of diseases.With the rapid development of microarray technology,whole-genome sequencing,whole-transcriptome sequencing and other highthroughput technologies,this study found that saliva is a potential huge biomarker repository and excavated many diseasespecific saliva markers.The saliva biomarkers were integrated for oral cancer and precancer screening.The advantages and disadvantages of using saliva as a biomarker in this field and as an improvement strategy were discussed to provide insights into the early diagnosis and treatment of oral cancer in the future.

关 键 词：唾液 口腔癌 癌前筛查 生物标志物 精准医疗 

分 类 号：R730.4[医药卫生—肿瘤]