乳腺癌术后至化疗的间隔时间对乳腺癌患者治疗效果的影响  

Effect of time gap between end of surgery and chemotherapy on the curative effect in breast cancer patients

作　　者：储春强[1] 华志元[1] 刘晓[1] 秦安[1] CHU Chunqiang;HUA Zhiyuan;LIU Xiao;QIN An(Department of Thyroid and Breast Surgery,Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi 210029,Jiangsu,China)

机构地区：[1]南京医科大学附属无锡市人民医院甲乳外科

出　　处：《癌症进展》2019年第24期2956-2958,共3页Oncology Progress

摘　　要：目的探讨乳腺癌术后至化疗的间隔时间对乳腺癌患者治疗效果的影响。方法根据术后化疗开始的时间不同将120例乳腺癌患者分为对照组(n=53)和观察组(n=67);对照组患者术后4~12周内开展化疗,观察组患者术后4周内开展化疗。比较两组患者的3年复发率、3年生存率及化疗期间不良反应发生情况;并对两组患者化疗前后疼痛情况及生活质量进行比较。结果观察组患者的3年复发率低于对照组,3年生存率高于对照组,差异均有统计学意义(P﹤0.05);化疗期间,两组患者的不良反应总发生率比较,差异无统计学意义(P﹥0.05);化疗后,两组患者的视觉模拟评分法(VAS)评分均低于本组化疗前,生活质量评分均高于本组化疗前,差异均有统计学意义(P﹤0.05);化疗后,观察组患者的VAS评分低于对照组,生活质量评分高于对照组,差异均有统计学意义(P﹤0.05)。结论乳腺癌根治术后早期拟定化疗方案,开展辅助化疗,可以降低患者的疼痛程度及不良反应发生率,提高患者的生存率。Objective To explore the effect of time gap between initiating chemotherapy and end of breast cancer surgery on the therapeutic effect in breast cancer patients.Method A total of 120 cases of breast cancer patients were included and divided into control group(n=53)and study group(n=67)according to the time of initiating postoperative chemotherapy after surgery.Patients in the control group received chemotherapy for 4 to 12 weeks after surgery;while the study group accepted chemotherapy within 4 weeks after surgery.The 3-year recurrence rate,3-year survival rate and adverse reactions during chemotherapy were compared between the two groups.The pain and quality of life of the two groups of patients were compared before and after chemotherapy.Result The 3-year recurrence rate in study group was lower than that of the control group,and the 3-year survival rate was higher than that of the control group,with statistically significant differences observed(P<0.05).During chemotherapy,there was no statistically significant difference in the overall incidence of adverse reactions between the two groups(P>0.05).After chemotherapy,the visual analogue scores(VAS)for pain in both groups of patients were all decreased as compared with that before chemotherapy,and their quality of life scores were also improved significantly(P<0.05);additionally,the VAS score of study group was lower compared to control group,and quality of life score was higher instead,with statistically significant differences noted(P<0.05).Conclusion Early planning for chemotherapy regimen and administration of adjuvant chemotherapy would help reduce the degree of pain and incidence of adverse reactions,resulting in improved survival rate.

关 键 词：乳腺癌 化疗时机 预后情况 

分 类 号：R737.9[医药卫生—肿瘤]