不同糖代谢异常状态卵巢癌患者的预后分析  

Prognostic analysis of ovarian cancer patients with abnormal glucose metabolism

作　　者：贺寅 郑蓉[1] 刘永珍[1] HE Yin;ZHENG Rong;LIU Yongzhen(Department of Gynecology,Taihe Hospital,Shiyan 442000,Hubei,China)

机构地区：[1]十堰市太和医院妇科

出　　处：《癌症进展》2019年第24期2991-2993,3008,共4页Oncology Progress

摘　　要：目的观察不同糖代谢异常状态卵巢癌患者的预后情况。方法将129例卵巢癌患者根据术前口服葡萄糖耐量试验(OGTT)结果分为正常血糖(Con)组52例、糖耐量降低(IGT)组47例、糖尿病(DM)组30例,比较3组患者的临床特征及生存情况。结果DM组中临床分期为Ⅲ~Ⅳ期的患者比例高于Con组与IGT组,DM组中有淋巴结转移的患者比例高于Con组,差异均有统计学意义(P﹤0.05)。DM组患者无进展生存期和总生存期均短于IGT组和Con组,IGT组患者无进展生存期和总生存期均短于Con组,差异均有统计学意义(P﹤0.05);生存曲线分析显示,3组患者生存情况比较,差异有统计学意义(P﹤0.05)。结论合并糖代谢异常的卵巢癌患者更易发生肿瘤复发,生存时间短,临床结局差,临床在卵巢癌治疗中应积极关注糖代谢水平,促进患者预后改善。Objective To assess the prognosis of ovarian cancer patients with different subtypes of abnormal glucose metabolism.Method The oral glucose tolerance test(OGTT)results of 129 patients with ovarian cancer obtained before surgery were retrospectively analyzed;according to the preoperative OGTT results,these patients were categorized as normal blood glucose(Con)group(n=52),impaired glucose tolerance(IGT)group(n=47),and diabetes mellitus(DM)group(n=30),the clinical characteristics and survival of the three groups of patients were compared.Result The proportion of patients with clinical stage III-IV disease in DM group was higher than Con group and IGT group,besides,proportion of patients with lymph node metastasis in DM group was higher compared to Con group,and the differences were of statistical significance(P<0.05).The progression-free survival(PFS)and overall survival(OS)of the DM group were shorter than those of the IGT group and Con group,and the IGT group had shorter PFS and OS than Con group(P<0.05);the survival curve revealed significant differences regarding the survival among the three groups of patients(P<0.05).Conclusion Presence of abnormal glucose metabolism significantly facilitates the recurrence of ovarian cancer,resulting in shorter survival time and poor clinical outcomes.In clinical practice,more attention should be paid to the level of glucose metabolism in the treatment of ovarian cancer so as to improve prognosis of patients.

关 键 词：糖代谢 血糖 卵巢癌 预后 

分 类 号：R737.31[医药卫生—肿瘤]