Sclerosing angiomatoid nodular transformation of the spleen, a rare cause for splenectomy: Two case reports  

作　　者：Sophia Chikhladze Ann-Kathrin Lederer Stefan Fichtner-Feigl Uwe A Wittel Martin Werner Konrad Aumann 

机构地区：[1]Department of General and Visceral Surgery,Medical Center-University of Freiburg,Faculty of Medicine,University of Freiburg,Freiburg 79106,Germany [2]Center for Complementary Medicine,Department of Infection Prevention and Hospital Epidemiology,Medical Center-University of Freiburg,Faculty of Medicine,University of Freiburg,Freiburg 79106,Germany [3]Institute of Surgical Pathology,Medical Center-University of Freiburg,Faculty of Medicine,University of Freiburg,Freiburg 79106,Germany

出　　处：《World Journal of Clinical Cases》2020年第1期103-109,共7页世界临床病例杂志

摘　　要：BACKGROUND Sclerosing angiomatoid nodular transformation(SANT)is a rare benign disease of the spleen with unknown origin.Clinical symptoms are inhomogeneous,and suspicious splenic lesion often found incidentally,leading to splenectomy,as malignancy cannot securely be ruled out.Diagnosis is made histologically after resection.CASE SUMMARY Two cases of German,white,non-smoking,and non-drinking patients of normal weight are presented.The first one is a 26-year-old man without medical history who was exhibiting an undesired weight loss of 10 kg and recurring vomiting for about 18 mo.The second one is a 65-year-old woman with hypertension who had previously undergone gynecological surgery,suffering from a lasting feeling of abdominal fullness.Both showed radiologically an inhomogeneous splenic lesion leading to splenectomy approximately 6 and 9 wk after surgical presentation.Both diagnoses of SANT were made histologically.Follow-up went well,and both were treated according to the recommendation for asplenic patients.CONCLUSION SANT is a rare cause of splenectomy and an incidental histological finding.Further research should focus on clinical and radiological diagnosis of SANT as well as on treatment of patients with asymptomatic and small findings.BACKGROUND Sclerosing angiomatoid nodular transformation(SANT) is a rare benign disease of the spleen with unknown origin. Clinical symptoms are inhomogeneous, and suspicious splenic lesion often found incidentally, leading to splenectomy, as malignancy cannot securely be ruled out. Diagnosis is made histologically after resection.CASE SUMMARY Two cases of German, white, non-smoking, and non-drinking patients of normal weight are presented. The first one is a 26-year-old man without medical history who was exhibiting an undesired weight loss of 10 kg and recurring vomiting for about 18 mo. The second one is a 65-year-old woman with hypertension who had previously undergone gynecological surgery, suffering from a lasting feeling of abdominal fullness. Both showed radiologically an inhomogeneous splenic lesion leading to splenectomy approximately 6 and 9 wk after surgical presentation.Both diagnoses of SANT were made histologically. Follow-up went well, and both were treated according to the recommendation for asplenic patients.CONCLUSION SANT is a rare cause of splenectomy and an incidental histological finding.Further research should focus on clinical and radiological diagnosis of SANT as well as on treatment of patients with asymptomatic and small findings.

关 键 词：SPLENECTOMY Sclerosing angiomatoid nodular transformation SPLEEN Abdominal discomfort Gastrointestinal dysfunction Case report 

分 类 号：R73[医药卫生—肿瘤]