On the immunological limitations of hibernation and synthetic torpor as a supporting technique for astronauts’ radioprotection in deep space missions  

作　　者：Joseph J Bevelacqua James Welsh Seyed Mohammad Javad Mortazavi 

机构地区：[1]Bevelacqua Resources,Richland,WA 99352,United States [2]Department of Radiation Oncology,Loyola Stritch School of Medicine,Hines VA Hospital Chicago,Chicago,IL 60153,United States [3]Shiraz University of Medical Sciences,Shiraz 7134845794,Iran

出　　处：《World Journal of Immunology》2019年第1期1-4,共4页世界免疫学杂志

摘　　要：Although human hibernation has been introduced as an effective technique in space exploration,there are concerns regarding the intrinsic risks of the approach(i.e.,synthetic torpor)and other factors involved in this procedure.Besides concerns about the brain changes and the state of consciousness during hibernation,an"Achilles heel"of the hibernation is the negative impact of torpor on factors such as the number of circulating leukocytes,complement levels,response to lipopolysaccharides,phagocytotic capacity,cytokine production,lymphocyte proliferation,and antibody production.Moreover,increased virulence of bacteria in deep space can significantly increase the risk of infection.The increased infection risk during long-term space missions with the combined effects of radiation and microgravity affect the astronauts’immune system.With these additional immune system stressors,torpor-induced extraimmunosuppression can be potentially life threatening for astronauts.Although human hibernation has been introduced as an effective technique in space exploration, there are concerns regarding the intrinsic risks of the approach(i.e., synthetic torpor) and other factors involved in this procedure. Besides concerns about the brain changes and the state of consciousness during hibernation, an "Achilles heel" of the hibernation is the negative impact of torpor on factors such as the number of circulating leukocytes, complement levels,response to lipopolysaccharides, phagocytotic capacity, cytokine production,lymphocyte proliferation, and antibody production. Moreover, increased virulence of bacteria in deep space can significantly increase the risk of infection.The increased infection risk during long-term space missions with the combined effects of radiation and microgravity affect the astronauts’ immune system. With these additional immune system stressors, torpor-induced extraimmunosuppression can be potentially life threatening for astronauts.

关 键 词：Space radiation HIBERNATION RADIOPROTECTION Synthetic torpor Immunology 

分 类 号：F42[经济管理—产业经济]