MR T2 mapping成像评估介入栓塞法制备的急性心肌缺血模型心肌组织特征  

MR T2 mapping in evaluation on myocardial tissue characteristics of acute myocardial ischemia models established with interventional embolization

作　　者：刘新峰[1] 李应龙[2] 曾宪春[1] 王荣品[1] 宋辉[1] 吴曙光 LIU Xinfeng;LI Yinglong;ZENG Xianchun;WANG Rongpin;SONG Hui;WU Shuguang(Department of Radiology,Guizhou Provincial People's Hospital,Guiyang 550002,China;Department of Intervention,Guizhou Provincial People's Hospital,Guiyang 550002,China;Animal Research Institute,Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China)

机构地区：[1]贵州省人民医院放射科,贵州贵阳550002 [2]贵州省人民医院介入科,贵州贵阳550002 [3]贵州省中医药大学动物研究所,贵州贵阳550002

出　　处：《中国介入影像与治疗学》2020年第1期43-46,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：国家自然科学基金培育项目[黔科合平台人才(2017)5724号];贵州省科技成果应用及产业化计划项目[黔科合成果(2019)4445号];贵州省人民医院青年基金[GZSYQN(2017)15号]

摘　　要：目的探讨MR T2 mapping成像评估介入栓塞法制备的急性心肌缺血模型心肌组织特征的可行性。方法对15头健康成年贵州小型猪以介入栓塞法制备急性心肌缺血模型,测量并对比建模前后左心室心肌T2值。结果13头建模成功,建模成功率86.67%(13/15)。建模前左心室心底、心中、心尖部心肌T2值总体差异无统计学意义(P=0.70);建模后总体差异有统计学意义(P<0.01),心底部心肌T2值小于心中及心尖部(P均<0.01),心中、心尖部差异无统计学意义(P>0.05)。建模后心中、心尖部心肌T2值均大于建模前(P均<0.01),建模前后心底部心肌T2值差异无统计学意义(P>0.05)。结论采用介入栓塞法建立急性心肌缺血模型的成功率较高;利用MR T2 mapping成像可对模型心肌缺血水肿程度进行定量分析。Objective To explore the feasibility of T2 mapping technology for evaluation on myocardial tissue characteristics of acute myocardial ischemia models established with interventional embolization.Methods Acute myocardial ischemia models were established with interventional embolization in 15 healthy adult Guizhou mini-swines.T2 values of left ventricular myocardium were measured and compared before and after modeling.Results Thirteen models were successfully established,and the success rate was 86.67%(13/15).There was no significant difference of T2 value of left ventricle myocardial bottom,middle and apex before modeling(P=0.70).The overall difference after modeling was statistically significant(P<0.01),and T2 value of cardiac bottom was lower than that of the heart and apex of left ventricle(both P<0.01),while there was no significant difference between the middle and the apex of left ventricle(P>0.05).T2 values of middle and apex of left ventricle after modeling were larger than those before modeling(both P<0.01).There was no significant difference of T2 value of myocardial base before and after modeling(P>0.05).Conclusion The success rate of establishing acute myocardial ischemia models with interventional embolization was high.The degree of myocardial ischemic edema can be quantitatively analyzed by using T2 mapping technique.

关 键 词：心肌缺血 栓塞 磁共振成像 猪 

分 类 号：R-332[医药卫生] R445.2