纳米炭对乳腺癌术后淋巴化疗转肩关节的跟踪效果及安全性价值  

Follow-up effect and safety value of nano-carbon on shoulder joint after lymphatic chemotherapy for breast cancer

作　　者：王丹[1] 孙圣荣[1] WANG Dan;SUN Sheng-rong(Department of Mammary and Thyroid Surgery, People's Hospital of Wuhan University wuhan430061, China)

机构地区：[1]武汉大学人民医院乳腺甲状腺外科

出　　处：《海南医学院学报》2019年第24期1893-1896,1901,共5页Journal of Hainan Medical University

基　　金：国家自然科学基金项目(81471781)~~

摘　　要：目的探讨纳米炭对乳腺癌术后淋巴化疗转肩关节的跟踪效果及安全性价值。方法选取164例乳腺癌患者,Sc组(紫杉醇+纳米炭),Dd组(紫杉醇),观察两组肩关节功能,观察两组12、24、36、48 h注射化疗患者紫杉醇浓度;转移淋巴结凋亡指数(AI)、淋巴结细胞凋亡率,观察两组不良反应发生情况。结果Sc组12、24、36、48 h注射化疗患者淋巴结内紫杉醇浓度明显高于Dd组,Sc组24 h注射化疗患者紫杉醇浓度最高,48 h注射化疗患者紫杉醇浓度最低(P<0.05);Sc组12、24、36、48 h注射化疗患者淋巴结细胞AI指数较Dd组明显升高(P<0.05)。两组36 h注射化疗患者淋巴结细胞AI指数与48 h时注射化疗患者AI指数比较,差异无统计学意义(P>0.05);Sc组12、24、36、48 h注射化疗患者淋巴细胞凋亡率较Dd组明显升高(P<0.05)。两组36 h注射化疗患者与48 h注射化疗患者的淋巴结细胞凋亡率比较,差异无统计学意义(P>0.05);Dd组不良反应发生率高于Sc组,差异无统计学意义(P>0.05);两组术前肩关节功能比较,差异无统计学意义(P>0.05),Sc组较Dd组肩关节功能评分分值有所增加(P<0.05)。结论纳米炭对乳腺癌术后淋巴化疗转肩关节中的应用价值较高,安全性较好,值得在临床治疗乳腺癌中广泛应用。Objective To investigate the effect and safety of nano-carbon on shoulder joint after lymphatic chemotherapy for breast cancer.Methods Altogether,164 patients with breast cancer were divided into the Sc group(docetaxel+CNP),and the Dd group(docetaxel).Shoulder joint function,docetaxel concentration after 12 h,24 h,36 h and 48 h injection of chemotherapy,apoptotic index of metastatic lymph nodes,apoptosis rate of lymph node cells of the two groups were observed.The occurrence of adverse reactions.ResultsThe concentration of paclitaxel in the lymph nodes of the Sc group was significantly higher than that of the Dd group at 12、24、36、48 h.The concentration of paclitaxel was the highest in the Sc group at 24 h,and the lowest in the 48 h group.P<0.05);The AI index of the Sc group was significantly higher than that of the Dd group at 12、24、36、48 h(P<0.05).The AI index of the 36 h and 48 h of the two groups were compared,andthe difference was not significant(P>0.05).The apoptosis rate of lymphocytes in the group of 12 h,24 h,36 h and 48 h in the Sc group was significantly higher than that in the Dd group(P<0.05).The patients in the Sc group and the Dd group were injected with chemotherapy for 48 h.There was no significant difference in lymph node cell apoptosis rate between the injection chemotherapy patients(P>0.05);the incidence of adverse reactions in the Dd group(15%)was higher than that in the Sc group(7.1%),but there was no difference(P>0.05);There was no significant difference in the function of shoulder between the two groups(P>0.05).The score of the shoulder joint function score in the Sc group was increased compared with the Dd group(P<0.05).ConclusionCarbon nanoparticles are of high value and safety in the application of lymphatic chemotherapy to shoulder joint after breast cancer surgery,which is worthy of wide application in clinical treatment of breast cancer.

关 键 词：纳米炭 乳腺癌 化疗 肩关节 

分 类 号：R737.9[医药卫生—肿瘤]