猴脑选择性超深低温断血流复苏对脑电功率谱的影响  

Effect of Monkey Brain Selective Ultra-deep Hypothermic Blood Flow Recovery on EEG Power Spectrum

作　　者：许智星 胡小刚 牛小群[1] 蒲军[1] XU Zhi-xing;HU Xiao-gang;NIU Xiao-qun;PU Jun(Dept.of Neurosurgery,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101;Dept.of Neurosurgery,Pu'er People's Hospital,Pu'er Yunnan 665000,China)

机构地区：[1]昆明医科大学第二附属医院神经外科,云南昆明650101 [2]普洱市人民医院神经外科,云南普洱665000

出　　处：《昆明医科大学学报》2019年第12期23-27,共5页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE467(-054)]

摘　　要：目的探讨选择性深低温灌注对猴脑严重缺血后脑电功率谱的影响。方法健康成年恒河猴3只,建立选择性超深低温断血流复温模型,使脑温维持在14.7℃~16.0℃,持续1 h,随后自然复温。全程予脑电图监测,随机采集常规电极信号,分析δ波、θ波、α波、β波4个频段的绝对功率值。结果脑电波幅随脑温降低而下降,主要以慢波为主,脑温降至18℃及以下时近乎呈直线状,复温后波幅随温度升高逐渐恢复。灌注期、低温维持期的绝对功率值与麻醉期相比差异有统计学意义(P<0.05),复温期则差异无统计学意义(P>0.05)。结论选择性脑超深低温具有脑保护作用,低温维持期主要存在以慢波(δ、θ)为主的脑电活动。Objective To explore the effect of selective deep hypothermic perfusion on brain power spectrum after severe ischemia in monkey brain. Methods Three healthy adult rhesus monkeys were selected to establish a selective ultra-deep hypothermia blood flow rewarming model to maintain the brain temperature at 14.7-16.0 ℃ for 1 hour, and finally rewarmed naturally. The whole process was monitored by EEG, and the conventional electrode signals were randomly collected to analyze the absolute power values of the four bands of δ wave, θ wave, αwave and β wave.Results The amplitude of brain wave decreased with the decrease of brain temperature,mainly slow wave. When the brain temperature dropped to 18 ° C and below, it was almost linear. After rewarming, the amplitude gradually recovered with the increase of temperature. The absolute power values during the perfusion period and the low temperature maintenance period were significantly different from those during the anesthesia period(P < 0.05), but there was no significant difference during the rewarming period(P > 0.05).Conclusion Selective brain ultra-low temperature has brain protection effect, and there are mainly EEG activities with slow wave (δ,θ) in the low temperature maintenance period.

关 键 词：恒河猴 选择性脑灌注 超深低温 脑电功率谱 

分 类 号：R743[医药卫生—神经病学与精神病学]