帕金森轻度认知障碍患者的临床特点及转归分析  

Clinical characteristics and prognosis of cognitive impairment in patients with Parkinson’s disease

作　　者：崔文娟 青绍华 刘莉[1] 陈秋[1] Cui Wenjuan;Qing Shaohua;Liu Li;Chen Qiu(Neurological Center,The Central Hospital of Suining,Suining 629000,China)

机构地区：[1]四川省遂宁市中心医院神经中心三病区

出　　处：《广西医科大学学报》2019年第12期1923-1926,共4页Journal of Guangxi Medical University

基　　金：四川省卫生和计划生育委员会科研课题资助项目(No.17PJ092)

摘　　要：目的:探讨帕金森病(PD)轻度认知障碍(PD-MCI)的特点及转归情况。方法:回顾性分析2017年1月至2019年1月四川省遂宁市中心医院神经内科收治的138例帕金森病轻度认知功能障碍(PD-MCI)患者的病例资料,分析临床特点,随访6~22个月记录疾病转归及进展情况,以转化为帕金森病痴呆(PDD)患者作为PDD组,以治疗后转为正常认知和保持PD-MCI状态作为非PDD组,探讨PDD的危险因素。结果:治疗后随访6~22个月,138例PD-MCI患者中,23例转为正常认知(16.67%),80例保持PD-MCI状态(57.97%),35例进展为PDD(25.36%)。PDD组年龄、婚姻状况、受教育年限、高血压、糖尿病、高血脂症、抑郁、睡眠障碍和基线MoCA评分与非PDD组比较,差异均有统计学意义(均P<0.05);多因素Logisitic回归分析显示:受教育年限<10年、高血压、睡眠障碍、基线MoCA评分<26分是PD-MCI转化为PDD的危险因素(均P<0.05)。结论:PD-MCI以高龄、低受教育年限患者为主,多数合并高血压病、糖尿病等基础疾病;受教育年限<10年、高血压、睡眠障碍、低基线MoCA评分均为PD-MCI患者接受治疗后仍进展为PDD的危险因素。Objective:To investigate the characteristics and prognosis of Parkinson's disease(PD)with mild cognitive impairment(PD-MCI).Methods:The data of 138 patients with PD-MCI treated in our hospital from January 2017 to January 2019 were retrospectively analyzed.All patients were followed up for 6-22 months in order to record the prognosis and risk factors of PD dementia(PDD).Results:The cognition of 23 cases recovered(16.67%),80 cases still had PD-MCI(57.97%),and 35 cases progressed to PDD(25.36%)during the follow-up in the 138 patients with PD-MCI.Age,marital status,education years,hypertension,diabetes,hyperlipidemia,depression,sleep disorders and the baseline MoCA score were significantly different between the PPD group and non-PDD group(P<0.05).Multivariate logisitic regression analysis showed that education years shorter than 10 years,hypertension,sleep disorders and baseline MoCA score<26 were the risk factors for PD-MCI transfer to PDD(P<0.05).Conclusion:The majority of patients with PD-MCI are of advanced age and have short education years,and most of them are complicated with hypertension,diabetes and other underlying diseases;education years<10 years,hypertension,sleep disorders and low baseline MoCA score are risk factors of PDD in patients with PD-MCI after treatment.

关 键 词：帕金森病 轻度认知功能障碍 危险因素 帕金森病痴呆 

分 类 号：R742.5[医药卫生—神经病学与精神病学]