基于闭环反馈控制的小动物长骨轴向压缩应力载荷加载系统的研制  

Development of axial compression load control system for animal long bone based on closed-loop feedback control

作　　者：邵希 罗二平 王佳晨 刘曦雨 颜泽栋 封颖 蔡婧 景达 SHAO Xi;LUO Er-ping;WANG Jia-chen;LIU Xi-yu;YAN Ze-dong;FENG Ying;CAI Jing;JING Da(School of Biomedical Engineering,Air Force Medical University,Xi'an 710032,China;Department of Biomedical Engineering,Chinese PLA General Hospital,Beijing 100853,China;Basic Medical College of Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi Province,China)

机构地区：[1]空军军医大学军事生物医学工程学系,西安710032 [2]解放军总医院医学工程保障中心,北京100853 [3]陕西中医药大学基础医学院,陕西咸阳712046

出　　处：《医疗卫生装备》2020年第1期12-16,共5页Chinese Medical Equipment Journal

基　　金：国家自然科学基金面上项目(51777211)

摘　　要：目的:设计一种基于LabVIEW的闭环反馈控制的小动物长骨轴向压缩应力载荷加载系统,实现对小动物长骨应力加载装置的程序控制。方法:该系统基于课题组前期设计的小动物长骨应力加载装置进行设计,增加闭环反馈模块和应变测量模块,并将步进电动机替换为伺服电动机,上位机发送的电动机运行控制指令经RS485串行通信接口发送至电动机控制器。结果:该系统可对小动物长骨施加频率可控、强度精准、模式一致的周期载荷;增加闭环反馈模块后可有效消除偏差、自动调整峰值载荷,提高了稳定性;应变测量模块可实时监测骨骼表面的应变变化情况。结论:该系统保证了加载载荷的有效性及精确性,解决了因骨组织蠕变效应造成的加载初期应力下降的问题,能够有效建立动物长骨载荷模型,为探索骨质疏松、应力性骨折等骨骼疾病的发病机制及预防治疗措施提供了实验平台。Objective To develop a closed-loop feedback axial compression load control system based on LabVIEW,which is used to concisely control a loading device.Methods Based on the animal compression loading device designed by the research group,the closed-loop feedback and strain measurement modules were added in the system to realize the function of precise control and real-time monitoring of the device by the computer via RS485 interface.Results The system could apply consistent load with accurate intensity,controllable frequency and pattern.Through the closed-loop feedback module,it could monitor whether the current applied stress was consistent with the set value.If a change occurred,the motor adjusted automatically to maintain the peak stress steadily.The strain measurement module monitored strain changes on the bone surface in real time.Conclusion The system improves the validity and accuracy of loading.It effectively solves the problem of stress instability caused by the creep effect of bone tissue,establishes animal long bone models as desired,and provides an experimental platform to explore the pathogenesis and preventive treatments of bone diseases such as osteoporosis and stress fracture.

关 键 词：轴向压缩载荷 闭环反馈控制 LabVIEW 应力 长骨 骨骼 

分 类 号：R318.6[医药卫生—生物医学工程] R197.39[医药卫生—基础医学]