银杏叶提取物治疗迟发性运动障碍与血浆锰超氧化物歧化酶的关系研究  

The study on the effect of ginkgo biloba extracts on MnSOD activity in the treatment of tardive dyskinesia

作　　者：吕梦涵[1] 郑军然 吴宇泽[1] 赵克新[1] 闫少校[1] LYU Menghan;ZHENG Junran;WU Yuze;ZHAO Kexin;YAN Shaoxiao(Department of integrated traditional Chinese and western medicine,Beijing Huilongguan Hospital,Changping District,Beijing 100096,China)

机构地区：[1]北京回龙观医院中西医结合科

出　　处：《中国神经精神疾病杂志》2019年第11期657-662,共6页Chinese Journal of Nervous and Mental Diseases

基　　金：首都卫生发展科研专项（编号：首发2016-4-2131）;北京市优秀人才培养资助（编号：2016000021469G174）

摘　　要：目的探讨银杏叶提取物(ginkgo biloba extract,EGb-761)是否可以通过提高血浆锰超氧化物歧化酶(manganese superoxide dismutase,MnSOD)活性来改善迟发性运动障碍(tardive dyskinesia,TD)症状。方法共纳入384例精神分裂症患者(157例TD患者,227例非TD患者)和280名正常对照,比较三组外周血浆MnSOD水平。对157例TD患者进行随机双盲安慰剂对照研究,EGb-761治疗组患者(n=78)每天服用240 mg EGb-761,安慰剂组(n=79)采用相同外观的空白胶囊,共治疗12周,在基线、治疗6周后和治疗12周后评估异常不自主运动量表(abnormal involuntary movement scale,AIMS)、阳性与阴性症状量表(positive and negative syndrome scale,PANSS),并在基线和治疗12周后测定血浆MnSOD活性。结果基线期TD组MnSOD血浆活性低于非TD组(P<0.05),且均低于正常对照组(P<0.01)。TD患者治疗前后AIMS总分组间效应(F=4.00,P=0.05)、时间效应(F=32.17,P<0.01)以及组间与时间交互效应(F=39.04,P<0.01)有统计学意义,治疗6周后和12周后EGb-761治疗组AIMS总分低于安慰剂组(均P<0.01)。治疗前后MnSOD活性时间效应(F=23.04,P<0.01)以及组间与时间交互效应(F=6.41,P=0.02)有统计学意义。另外,EGb-761治疗组的基线期MnSOD水平与治疗期间AIMS总分减分值相关(r=0.27,P=0.02)。结论EGb-761治疗能改善TD症状、提高MnSOD活性。Objective To investigate if ginkgo biloba extract(EGb-761)can improve tardive dyskinesia(TD)symptoms through increasing the activity of plasma MnSOD.Methods We enrolled a total of 384 schizophrenia patients including 157 TD patients and 227 non-TD patients,as well as 280 normal subjects.The difference of MnSOD level in plasma among these groups were compared.TD patients were then randomly divided into two groups.The treatment group(n=77)and the placebo group(n=75)were treated with 240 mg of EGb-761 or placebo per day for 12 weeks,respectively.The abnormal involuntary movement scale(AIMS)and the positive and negative symptoms scale(PANSS)were used to evaluate the severity of the symptoms in baseline,the sixth week and the twelfth week after treatment.The level of MnSOD activity in plasma was also detected before and after the treatment.Results The level of MnSOD activity was lower in schizophrenia groups than in healthy control group(P<0.01).In addition,the level of MnSOD activity was significantly lower in TD group than in non-TD group(P<0.05).Repeated measures analysis of variance showed that group effect(F=4.00,P=0.05),time effect(F=32.17,P<0.01)and interactive effect of group and time(F=39.04,P<0.01)were significant in AIMS total score.The AIMS total score of treatment group was significantly lower than that of placebo group at 6-week and 12-week time points(all P<0.01).Repeated measures analysis of variance showed that time effect(F=23.04,P<0.01)and interactive effect of group and time(F=6.41,P<0.05)were significant in the level of MnSOD activity.In addition,the level of MnSOD at baseline was significantly correlated with the reduction of AIMS total score during the treatment period(r=0.27,P=0.018).Conclusion Treatment of EGb-761 can improve symptoms of TD and activity of MnSOD.

关 键 词：银杏叶提取物 迟发性运动障碍 锰超氧化物歧化酶 随机双盲对照研究 

分 类 号：R749.3[医药卫生—神经病学与精神病学]