从磷酰化氨基酸到丝组二肽  

Discovery of Seryl-Histidine Dipeptide: From N-phosphoryl Amino Acids to Functional Dipeptides

作　　者：赵玉芬 ZHAO Yufen(College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,Fujian Province,P.R.China;Institute of Drug Discovery Technology,Ningbo University,Ningbo 315211,Zhejiang Province,P.R.China)

机构地区：[1]厦门大学化学化工学院 [2]宁波大学新药技术研究院

出　　处：《大学化学》2019年第12期86-90,共5页University Chemistry

基　　金：国家自然科学基金(21778042,91856126)

摘　　要：磷是重要的生命元素之一,参与生命活动的各种生化反应进程。L-氨基酸是组成蛋白质的基本结构单元,氨基酸的N-磷酸化,使氨基酸分子被激活,成为一种"微型活化酶",可以发生多种生化反应,比如成肽反应。丝组二肽(L-丝氨酰-L-组氨酸)就是在N-磷酸化氨基酸的成肽反应过程中产生,并发现是具有多种生物酶活性的最小的功能肽,是现代水解酶的原始进化雏形。本文详细回顾了从N-磷酸化氨基酸到丝组二肽发现的研究历程,有痛苦、有迷茫,也有欢喜,充分体现了科学探索的魅力所在。Phosphorus is one of the important elements for life, which participates in various biochemical processes. L-Amino acids are the basic structural units of proteins. N-phosphorylation of amino acids makes them be activated and become one kind of "micro activating enzyme", which possesses a variety of biochemical reaction activities, such as peptide formation. Based on the peptide formation reaction of N-phosphoryl amino acids, L-seryl-L-histidine dipeptide(Seryl-histidine dipeptide) is produced and found that it is the smallest functional peptide with a variety of biological enzyme activities. Seryl-histidine dipeptide could be regarded as the original evolution prototype of modern hydrolytic enzyme. This paper reviews the research process from N-phosphoryl amino acids to the discovery of serylhistidine dipeptide in detail. There are pain, confusion and joy, which fully embodies the charm of scientific exploration.

关 键 词：磷 磷酰化氨基酸 丝组二肽 

分 类 号：G64[文化科学—高等教育学] O62[文化科学—教育学]