探究肌苷注射液联合醒脑静治疗CO中毒迟发性脑病的疗效观察  

To investigate the efficacy of inosine injection combined with Xingnaojing in the treatment of delayed encephalopathy caused by CO poisoning

作　　者：熊维 XiongWei(Department of Pharmacy,Macheng People's Hospital,Macheng,Hubei,438300,China)

机构地区：[1]麻城市人民医院药剂科

出　　处：《当代医学》2020年第3期36-38,共3页Contemporary Medicine

摘　　要：目的探究肌苷注射液联合醒脑静治疗一氧化碳(CO)中毒迟发性脑病(delayed encephalopathy after acute carbon monoxide poisoning,DEACMP)的疗效观察。方法选取2016年5月至2018年5月本院收治的85例DEACMP患者,根据给药治疗方案不同分为A组45例和B组40例,A组给予肌苷注射液联合醒脑静注射液治疗,B组仅给予肌苷注射液治疗。治疗前后对所有患者进行精神状态评估、实验室指标检测及疗效判定。结果两组治疗后简易智能精神状态量表(MMSE)评分、蒙特利尔量表(MoCA)评分及改良Barthel指数评分均明显升高,A组升高幅度明显大于B组,差异有统计学意义(P<0.05)。两组治疗前氧化应激、心肌损伤指标水平比较差异无统计学意义;治疗后血清超氧化物歧化酶(SOD)明显升高,丙二醛(MDA)、肌钙蛋白(cTnI)、磷酸肌酸激酶(CK)明显降低,A组SOD升高幅度及MDA、cTnI、CK降低幅度明显大于B组,差异有统计学意义(P<0.05)。治疗后A组总有效率为95.56%,明显高于B组的80.00%,差异有统计学意义(P<0.05)。结论在肌苷注射液治疗基础上联合应用醒脑静可有效缓解一氧化碳中毒迟发性脑病患者大脑、心肌损伤,提高临床疗效。Objective To investigate the efficacy of inosine injection combined with Xingnaojing in the treatment of delayed encephalopathy caused by carbon monoxide(CO) poisoning(DEACMP). Methods 85 patients with DEACMP admitted to our hospital from May 2016 to May2018, they were divided into 45 patients in group A and 40 patients in group B according to the different treatment regimens. Group A was treated with inosine injection combined with Xingnaojing injection, and group B was given only inosine injection treatment. All patients were evaluated for mental status, laboratory indicators, and efficacy before and after treatment. Results The scores of the simple intelligence mental state scale(MMSE), the Montreal scale(MoCA) and the modified Barthel index(MBI) were significantly higher in the two groups, but the increase in group A was significantly higher than that in group B, the difference was significant(P<0.05). There was no significant difference in the levels of oxidative stress and myocardial injury before treatment. Serum superoxide dismutase(SOD) was significantly increased after treatment. Malondialdehyde(MDA), troponin(cTnI) and phosphocreatine kinase(CK) was significantly decreased, but the increase of SOD and the decrease of MDA, cTnI and CK in group A were significantly higher than those in group B(P<0.05). After treatment, the total effective rate of group A was 95.56%, which was significantly higher than that of group B(80.00%). The difference was significant(P<0.05). Conclusion The combination of Xingnaojing on the treatment of inosine injection can effectively alleviate brain and myocardial damage in patients with DEACMP and improve clinical efficacy.

关 键 词：肌苷注射液 醒脑静 一氧化碳中毒迟发性脑病 临床疗效 

分 类 号：R74[医药卫生—神经病学与精神病学]