Predicative value of urinary protein biomarkers on delayed renal involvement in children with Henoch-Sch?nlein purpura  

作　　者：Haipeng Liu Wei Cui Hongjuan Liu Chenyu Zhang 

机构地区：[1]Clinical Laboratory Center,Anhui Provincial Childrens Hospital,Hefei 230051,China [2]Medical Laboratory Center,Anhui Institute of Pediatric Research,Hefei 230051,China [3]Medical Laboratory Center,Childrens Hospital of Anhui Medical University,Hefei 230051,China [4]Department of Scientific Research,Anhui Provincial Children's Hospital,Hefei 230051,China

出　　处：《Science China(Life Sciences)》2019年第12期1594-1596,共3页中国科学（生命科学英文版）

基　　金：supported by the Key Research and Development Program Projects in Anhui, China (1704a0802172)

摘　　要：Dear Editor,Henoch-Schonlein purpura(HSP)is one of the most common vasculitides in children with the incidence of 10-30 cases per 100,000 per year(Chen and Mao,2015)and its prognosis primarily depends on the extent of renal involvement.However,the onset of renal involvement may be delayed for weeks or months after the appearance of acute symptoms in HSP patients and easily be omitted(Mao et al.,2014).The increased urine protein biomarkers were remarkable indicators of early renal damage or early renal tubular function damage(Zulu et al.,2016)and had a great potential for early prognosis of HSP,but seldom do relationship between these biomarkers and later renal impairments of HSP were analyzed.This study aimed to investigate the relationship of several urinary protein levels during the acute stage of HSP,including N-acetyl-beta-D-glucosaminidase(NAG),p2-microglobulin(P2-MG),retinol-binding protein(RBP),transferrin(TRF),immunoglobulin G(IgG)and microalbumin(MA),with the risk of subsequent renal involvement after acute phase in HSP.

关 键 词：INVOLVEMENT URINARY URINE 

分 类 号：R72[医药卫生—儿科]