Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study  

作　　者：Peipei Jiang Xiaoqiu Tang Huiyan Wang Chenyan Dai Jing Su Hui Zhu Minmin Song Jingyu Liu Ziqing Nan Tong Ru Yaling Li Jingmei Wang Jun Yang Bing Chen Jianwu Dai Yali Hu 

机构地区：[1]Department of Obstetrics and Gynecology,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China [2]Center for Reproductive Medicine,Department of Obstetrics and Gynecology,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China [3]Nanjing Drum Tower Hospital,Chinese Academy of Medical Science&Peking Union Medical Collage,Nanjing 210008,China [4]Department of Pathology,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China [5]Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Science China(Life Sciences)》2019年第12期1617-1629,共13页中国科学（生命科学英文版）

基　　金：supported by The Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01030505);Jiangsu Provincial Key Medical Center (YXZXB2016004);Key Research and Development Program of Jiangsu Province (BE2016612);National Natural Science Foundation of China (81771526);Excellent Youth Natural Science Foundation of Jiangsu Province (BK20170051);Six Talent Peaks Projects in Jiangsu Province (WSW-074)

摘　　要：Intrauterine adhesion(IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2(b FGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of b FGF100 μg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients(2–4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were improved.Histological study showed blood vessel density increased obviously. Three patients(3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the b FGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis.Intrauterine adhesion(IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2(b FGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of b FGF100 μg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients(2–4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were improved.Histological study showed blood vessel density increased obviously. Three patients(3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the b FGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis.

关 键 词：intrauterine adhesion CBD-bFGF endometrial scarring uterine infertility thin endometrium endometrial reconstruction 

分 类 号：R73[医药卫生—肿瘤]