骨创治疗仪联合骨愈灵胶囊辅助治疗创伤性骨折临床研究  

Effect of bone trauma therapeutic instrument combined with Guyuling capsule on traumatic fracture

作　　者：王成龙 罗岳 李存宽 Wang Chenglong;Luo Yue;Li Cunkuan(Department of Orthopedics,Chinese Medicine Hospital of Ping'an District,Haidong 810600,China)

机构地区：[1]青海省海东市平安区中医医院骨科,810600

出　　处：《国际中医中药杂志》2019年第12期1333-1337,共5页International Journal of Traditional Chinese Medicine

摘　　要：目的探讨骨创伤治疗仪联合骨愈灵胶囊辅助治疗创伤性骨折的效果。方法将符合入选标准的168例创伤性骨折患者根据不同治疗方法分为骨创伤治疗仪组54例,骨愈灵胶囊组52例,联合组62例。所有患者均接受骨折内固定术治疗,术后常规给予抗感染、消肿、止痛等对症治疗。骨创伤治疗仪组在常规治疗基础上辅助骨创伤治疗仪治疗,骨愈灵胶囊组在常规治疗基础上加服骨愈灵胶囊,联合组同时给予骨创伤治疗仪+骨愈灵胶囊治疗。3组均连续治疗4周,随访3个月。采用双抗体夹心ELISA法检测血清表皮细胞生长因子(epidermal growth factor,EGF)、TGF-β1、VEGF水平,观察并记录患者消肿时间、骨折愈合时间,评价临床疗效。结果联合组消肿时间[(8.37±2.84)d比(10.76±4.17)d、(11.64±3.98)d,F=12.329]及愈合时间[(11.73±3.44)周比(14.23±4.62)周、(14.76±5.17)周,F=7.835]均较骨创伤治疗仪组和骨愈灵胶囊组缩短(P<0.01)。治疗后,联合组血清EGF[(0.60±0.27)µg/L比(0.75±0.35)µg/L、(0.72±0.37)µg/L,F=3.406]、TGF-β1[(9.28±4.19)µg/L比(12.36±4.21)µg/L、(12.86±4.69)µg/L,F=11.568]、VEGF[(92.58±26.01)pg/ml比(132.69±28.01)pg/ml、(127.63±29.85)pg/ml,F=36.053]水平均低于骨创伤治疗仪组与骨愈灵胶囊组(P<0.01)。随访3个月,骨创伤治疗仪组治愈率为35.2%(19/54)、总有效率为81.5%(44/54),骨愈灵胶囊组分别为34.6%(18/52)、82.7%(43/52),联合组分别为54.8%(34/62)、95.2%(59/62)。联合组治愈率及总有效率优于骨创伤治疗仪组与骨愈灵胶囊组(χ^2值分别为6.373、4.669,P值分别为0.041、0.031)。结论骨创伤治疗仪联合骨愈灵胶囊可促进创伤性骨折患者骨折的愈合,减轻骨折所引发的机体应激反应,提高临床疗效。Objective To investigate the effects of bone trauma therapy instrument combined with Guyuling capsule in the treatment of traumatic fractures and the effects on the levels of serum epidermal growth factor(EGF),transforming growth factor-1(TGF-β1)and vascular endothelial growth factor(VEGF).Methods The clinical data of 168 patients with traumatic fractures admitted to our hospital from January 2015 to December 2017 were retrospectively analyzed.According to different treatment methods,the patients were divided into the bone trauma treatment instrument group(54 cases),the bone Guyuling capsule group(52 cases)and the combined group(62 cases).All patients were treated with open internal fixation and routine anti-infection,detumescence,analgesic and other symptomatic treatment.The bone trauma therapeutic instrument group was given auxiliary treatment with bone trauma therapeutic instrument on the basis of conventional treatment,the bone healing capsule group was added with bone healing capsule treatment on the basis of conventional treatment,and the bone trauma therapeutic instrument and bone healing capsule combined treatment were given in the combined group at the same time.The clinical efficacy was compared and the serum levels of EGF,TGF-β1 and VEGF in the three groups were detected.Results The detumescence time(8.37±2.84 d vs.10.76±4.17 d,11.64±3.98 d,F=12.329)and the healing time(11.73±3.44 week vs.14.23±4.62 week,14.76±5.17 week,F=7.835)of the combined group were significantly shorter than those of the bone trauma therapy group and the Guyuling capsule group(P<0.01).After treatment,the serum EGF(0.60±0.27μg/L vs.0.75±0.35μg/L,0.72±0.37μg/L,F=3.406),TGF-β1(9.28±4.19μg/L vs.12.36±4.21μg/L,12.86±4.69µg/L,F=11.568),VEGF(92.58±26.01 pg/ml vs.132.69±28.01 pg/ml,127.63±29.85 pg/ml,F=36.053)were significantly lower than those in the bone trauma therapy group and the Guyuling capsule group(P<0.01).Three months after operation,the cure rate was 35.2%(19/54)and the total effective rate was 81.5%(44

关 键 词：骨折 闭合性 骨折固定术 内 骨愈灵胶囊 骨创伤治疗仪 血管内皮生长因子 

分 类 号：R73[医药卫生—肿瘤]