LncRNAs与心脏重构研究进展  

Progress of lncRNAs in myocardial remodeling

作　　者：张博文 张明宇[1] 姜媛 孙佳斌 伍江姣 许超千[1,2] ZHANG Bo-wen;ZHANG Ming-yu;JIANG Yuan;SUN Jia-bin;WU Jiang-jiao;XU Chao-qian(Department of Pharmacology,State-Province Key Laboratories of Biomedicine-Pharmaceutics of China,Key Laboratory of Cardiovascular Medicine Research,Ministry of Education,College of Pharmacy,Harbin Medical University,Harbin 150081;Chronic Diseases and Medicines Research Center,Mudanjiang Medical University,Mudanjiang 157011,China)

机构地区：[1]哈尔滨医科大学药理学教研室省部共建生物医药国家重点实验室,黑龙江哈尔滨150081 [2]牡丹江医学院慢病与药物研究中心,黑龙江牡丹江157011

出　　处：《解剖科学进展》2019年第6期713-716,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(304000591)

摘　　要：心脏重构主要表现为心肌受到外界刺激后引发的一种病理性改变,包括心肌细胞肥大,凋亡,自噬以及成纤维细胞的分化和增殖等病理过程,最终导致心脏体积增大,心肌重量增加,产生心功不全、心力衰竭等严重的心血管疾病。有证据表明,通过调控不同功能的长链非编码RNA(lncRNAs)在相关心脏疾病中的表达水平,可以加重或逆转心脏重构的病理过程。因此,lncRNAs作为心脏重构的重要调节靶点,有望成为治疗心脏重构的新的研究方向。Myocardial remodeling refers to a pathological change that occurs after myocardial stress, including hypertrophy, apoptosis and autophagy of cardiomyocytes, differentiation and proliferation of fibroblasts, eventually leading to the increased volume and quality of heart, and contributing to cardiovascular diseases such as cardiac dysfunction and heart failure. The evidence suggests that it can aggravate or reverse cardiac remodeling by regulating the expression level of different functional lncRNAs in corresponding diseases. Therefore, lncRNAs are expected to become a new research direction served as important therapeutic targets for cardiac remodeling.

关 键 词：心脏重构 LncRNAs 心肌细胞凋亡 lncRNAs 

分 类 号：R363.1[医药卫生—病理学]