尿激酶联合拜阿司匹林、硫酸氯吡格雷治疗急性脑梗死的临床疗效分析  

Clinical Analysis of Urokinase Combined with Aspirin and Clopidogrel Sulfate in the Treatment of Acute Cerebral Infarction

作　　者：黄新 HUANG Xin(Tongzhou Tongshan Hospital of Traditional Chinese Medicine,Xuzhou,Jiangsu Province,221116 China)

机构地区：[1]徐州市铜山区中医院普内科

出　　处：《系统医学》2019年第23期135-137,共3页Systems Medicine

摘　　要：目的研究急性脑梗死患者采用尿激酶、拜阿司匹林、硫酸氯吡格雷3种药物联合方式进行治疗的临床效果。方法2016年1月—2019年7月选择在该院进行药物治疗60例急性脑梗死患者,以随机分组的方式分成对照组(30例)和治疗组(30例)。对照组采用阿加曲班、拜阿司匹林、硫酸氯吡格雷3种药物联合方式进行治疗;治疗组采用尿激酶、拜阿司匹林、硫酸氯吡格雷3种药物联合方式进行治疗。结果治疗组患者药物治疗总有效率达到90.0%,高于对照组的63.3%(χ^2=4.520,P<0.05);治疗组患者中仅1例发生药物不良反应,对照组患者中有6例发生药物不良反应,两组差异有统计学意义(χ^2=4.380,P<0.05);用药前后NIHSS评分、生活质量评分、超敏C反应蛋白水平的改善幅度大于对照组(P<0.05);神经功能恢复正常时间、住院治疗总时间短于对照组(P<0.05);治疗组患者满意度为93.3%,高于对照组的66.7%(χ^2=4.330,P<0.05)。结论急性脑梗死患者采用尿激酶、拜阿司匹林、硫酸氯吡格雷3种药物联合方式进行治疗,可以减少药物不良反应的发生率,使脑神经功能、生活质量得到大幅度改善,有效缩短病情恢复时间、住院治疗时间,使疾病治疗效果和患者满意度得到同步提升。Objective To study the clinical effects of urokinase,aspirin and clopidogrel sulfate in the treatment of acute cerebral infarction.Methods Sixty patients from Jan 2016 to July 2019 with acute cerebral infarction were enrolled in the hospital.They were randomly divided into control group(30 cases)and treatment group(30 cases).The control group was treated with argatroban,aspirin and clopidogrel sulfate.The treatment group was treated with urokinase,aspirin and clopidogrel sulfate.Results The total effective rate of drug treatment in the treatment group was 90.0%,which was higher than 63.3% in the control group(χ^2=4.520,P<0.05).Only 1 patient in the treatment group developed adverse drug reactions,and adverse drug reactions of 6 patients in the control group occurred,the difference between the two groups was statistically significant(χ^2=4.380,P<0.05);the improvement of NIHSS score,quality of life score and high-sensitivity C-reactive protein level before and after treatment was greater than that of the control group(P<0.05);the time of neurological function to return to normal and hospitalization was shorter than that of the control group(P<0.05).The satisfaction of the treatment group was 93.3%,which was higher than that of the control group 66.7%(χ^2=4.330,P<0.05).Conclusion Patients with acute cerebral infarction treated with urokinase,aspirin and clopidogrel sulfate can reduce the incidence of adverse drug reactions,improve brain function and quality of life,and effectively shorten the recovery time.The time of hospitalization has improved the treatment effect of patients and patient satisfaction.

关 键 词：急性脑梗死 尿激酶 拜阿司匹林 硫酸氯吡格雷 不良反应 

分 类 号：R743[医药卫生—神经病学与精神病学]