血清自身抗体检测对自身免疫性肝病的研究进展  

Research progress of serum autoantibodies detection for autoimmune liver disease

作　　者：何亚男 郑长清[1] HE Ya’nan;ZHENG Changqing(Department of Gastroenterology,Shengjing Hospital,China Medical University,Shenyang 110021,China)

机构地区：[1]中国医科大学附属盛京医院消化内科

出　　处：《胃肠病学和肝病学杂志》2020年第1期104-107,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：自身免疫性肝病(autoimmune liver disease,AILD)是因自身免疫异常所致的以肝脏为相对特异性免疫病理损伤器官的一组疾病,主要包括自身免疫性肝炎(autoimmune hepatitis,AIH)、原发性胆汁性胆管炎(primary biliary cholangitis,PBC)、原发性硬化性胆管炎(primary sclerosing cholangitis,PSC)及重叠综合征。AILD与病毒感染、酒精、药物等所致的传统肝病不同,突出特点是血清中存在特异性的自身抗体。本文主要对AILD相关血清自身抗体的研究进展作一概述,以有助于临床诊断。Autoimmune liver disease(AILD)is a group of diseases caused by autoimmune abnormalities,in which the liver is relatively specific and immunopathologically damaged,including autoimmune hepatitis(AIH),primary biliary cholangitis(PBC),primary sclerosing cholangitis(PSC)and overlap syndromes.Different from traditional liver diseases caused by viral infection,alcohol and drugs,AILD is characterized by the presence of specific autoantibodies in serum.This article mainly reviewed the research progress of serum autoantibodies related to AILD,which is helpful for clinical diagnosis.

关 键 词：自身免疫性肝炎 原发性胆汁性胆管炎 原发性硬化性胆管炎 重叠综合征 自身抗体 诊断 

分 类 号：R575[医药卫生—消化系统]