子宫颈癌细胞学新型生物标志、诊断标志物的筛选和开发现状  

Screening and development of new biomarkers and diagnostic biomarkers for cervical cancer

作　　者：李红芳 赵小环 王丽萍 许晓燕 孙高高 Li Hongfang;Zhao Xiaohuan;Wang Liping;Xu Xiaoyan;Sun Gaogao(Department of Obstetrics&Gynecology,the First People's Hospital of Lanzhou City,Lanzhou 730050,China)

机构地区：[1]甘肃省兰州市第一人民医院妇产科

出　　处：《中华细胞与干细胞杂志（电子版）》2019年第6期375-384,共10页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：甘肃省科技厅重点研发计划-社会发展类课题（17YF1FA141）

摘　　要：子宫颈癌至今仍是全球范围内一个重要的公共卫生问题,是妇女疾病死亡的主要原因之一。因此,子宫颈癌细胞学的筛查、早期诊断和治疗越来越受到重视,虽然新的技术不断推出使子宫颈癌的早期筛查及诊治水平有了很大提高,但仍缺乏新型的特异性生物学标志物。本文从新的子宫颈癌相关蛋白生物标志物和诊断靶标的发现,治疗子宫颈癌的药物作用、治疗靶标和作用机制的评估,子宫颈癌相关微小核糖核酸作为诊断和治疗靶标的筛选等方面对子宫颈脱落细胞筛查方法的开发和研究进展进行综述,为子宫颈癌的早期筛查和诊断寻找新的生物学标志物。Cervical cancer is still an important public health problem in the world,which is one of the main causes of women's death.Therefore,more and more attention has been paid to cervical cancer cytology screening and early diagnosis and treatment.At present,with the continuous introduction of new technologies,the early screening and diagnosis of cervical cancer has been greatly improved,but there is still a lack of new specific biomarkers.In this paper,the development and research progress of screening methods for cervical exfoliated cells are reviewed,in order to find new biomarkers for early screening and diagnosis of cervical cancer.

关 键 词：子宫颈癌细胞 生物学标志物 筛查 诊断 

分 类 号：R73[医药卫生—肿瘤]