FOXK1基因的生物特性及其在肿瘤中的研究进展  

Biological characteristics of FOXK1 and its research progress in various tumors

作　　者：李燕[1,2] 陈瑜 何美芝 卞小慧 涂令境 崔春晖[1,2] 谢朗[1,2] LI Yan;CHEN Yu;HE Meizhi;BIAN Xiaohui;TU Lingjing;CUI Chunhui;XIE Lang(Department of General Surgery,Zhujiang Hospital of Southern Medical University,Guangzhou 510282,China;Second Clinical Medical College,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学珠江医院普通外科,广东广州510282 [2]南方医科大学第二临床医学院,广东广州510515

出　　处：《分子影像学杂志》2019年第4期518-523,共6页Journal of Molecular Imaging

基　　金：广东省科技计划基金（2017ZC0103）;国家自然科学基金（81600444）;大学生创新创业训练计划项目（201712121157）

摘　　要：叉头框K1(FOXK1)是近年来广受研究关注的FOX转录因子家族成员之一。越来越多的研究表明,FOXK1与生殖、神经和消化等多种系统的肿瘤密切相关,FOXK1可通过调节细胞周期、细胞自噬以及介导信号转导通路,参与各个系统肿瘤的发生发展,影响肿瘤侵袭、转移及患者的预后。FOXK1在各个系统肿瘤组织中的特异性表达及其作用机制的研究,为肿瘤的诊治提供了新方向。本文就FOXK1的基因特征、生物学功能及其与各系统肿瘤的关系进行综述并作展望。Fork head box 1(FOXK1)is one of the members of the FOX transcription factors family that has attracted increasing attention in recent years.More and more studies have shown that FOXK1 is closely related to various tumors such as cancer of reproductive,nervous and digestive systems.Through regulating cell cycle,autophagy and mediating signal pathway,FOXK1 influences tumor invasion and metastasis.It affecting the prognosis of patients.The research of expression of FOXK1 in various tumor tissues and its mechanism provide a new direction for the diagnosis and treatment of tumors.

关 键 词：FOXK1基因 WNT/Β-CATENIN信号通路 肿瘤 

分 类 号：R73[医药卫生—肿瘤]