趋化因子受体CXCR7在牙周炎中的表达及其作用机制  

Expression of Chemokine Receptor CXCR7 in Periodontitis and Its Mechanism

作　　者：张研[1] 辛琪[2] 马喆[2] 魏蓉 李晓冬[4] 苏瑞 张源 ZHANG Yan;XIN Qi;MA Zhe;WEI Rong;LI Xiaodong;SU Rui;ZHANG Yuan(Department of Periodontology,Tianjin Stomatology Hospital,Tianjin 300041,China;Department of Pathology,Third Central Hospital of Tianjin,Tianjin 300170,China;Nankai University,Tianjin 300071,China;Department of Clinical Laboratory,Mudanjiang First People's Hospital,Mudanjiang 157011,China)

机构地区：[1]天津市口腔医院牙周科,天津300041 [2]天津市第三中心医院病理科,天津300170 [3]南开大学,天津300071 [4]牡丹江市第一人民医院检验科,黑龙江牡丹江157011

出　　处：《口腔医学研究》2020年第1期46-50,共5页Journal of Oral Science Research

基　　金：国家自然科学基金孵育项目(No.2017YNY3)

摘　　要：目的:探讨CXCR7在牙周炎中的表达、分布及SDF-1/CXCR7生物学轴在牙周炎中的作用。方法:运用免疫组化的方法检测SDF-1、CXCR4、CXCR7在15例正常的牙龈组织和15例牙周炎组织中的表达,同时运用PCR方法检测15例正常的牙龈组织和15例牙周炎组织中的表达情况。结果:免疫组化和PCR的结果均显示SDF-1、CXCR4、CXCR7在牙周炎组织中表达增高,高于正常牙龈组织(P<0.05)。SDF-1与CXCR7呈正相关关系(γ=0.533,P=0.041)。CXCR4和CXCR7的表达呈正相关关系(γ=0.533,P=0.041)。结论:CXCR7在牙周炎微环境中的不同细胞群过表达,在牙周炎的病理过程中发挥作用,可能是治疗牙周炎的一个新的作用靶点。Objective:To investigate the expression and distribution of CXCR7 in periodontitis and the role of SDF-1/CXCR7 biological axis in periodontitis.Methods:Immunohistochemical method and PCR were used to detect the expression of SDF-1,CXCR4,and CXCR7 in 15 normal gingival tissues and 15 periodontitis tissues.Results:The expressions of SDF-1,CXCR4,and CXCR7 in periodontitis tissues were higher than those in normal gingival tissues(P<0.05).There was a positive correlation between SDF-1 and CXCR7(γ=0.533,P=0.041),and between CXCR4 and CXCR7(γ=0.533,P=0.033,P<0.01).CXCR7 was expressed in inflammatory cells of periodontitis and vascular endothelial cells associated with inflammation.Conclusion:The overexpression of CXCR7 in the microenvironment of periodontitis may play a role in the pathological process of periodontitis,which may be a new target for the treatment of periodontitis.

关 键 词：SDF-1 CXCR4 CXCR7 牙周炎 

分 类 号：R781.42[医药卫生—口腔医学]