表面修饰糖类化合物的纳米粒子主动靶向肿瘤的研究进展  

Research progress of surface-modified sugar nanoparticles active targeting on tumors

作　　者：张长梅 陈重 唐雪枫 李明慧[1] ZHANG Changmei;CHEN Zhong;TANG Xuefeng;LI Minghui(Pharmaceutical Preparation Teaching and Research Section,Daqing Campus of Harbin Medical University,Heilongjiang Province Daqing,163319,China)

机构地区：[1]哈尔滨医科大学大庆校区药物制剂教研室

出　　处：《中国医药导报》2019年第34期61-64,共4页China Medical Herald

基　　金：黑龙江省省属高等学校基本科研业务费基础研究项目(2017JCZX08);黑龙江省自然科学基金项目(QC2015130);哈尔滨医科大学大庆校区“校内科研基金”项目(DQXN201603)

摘　　要：纳米制剂表面经糖类化合物修饰后可实现肿瘤靶向给药,提高药物抗肿瘤作用。本文综述以不同类型糖类化合物为转运底物设计的纳米药物的肿瘤靶向作用研究,阐述糖配体修饰的纳米靶向剂型的优点。同时基于Warburing效应和葡萄糖转运体转运过程来研究糖配体修饰的纳米药物的抗肿瘤作用机制。糖配体修饰的纳米制剂有效控制或者利用葡萄糖转运体在Warburg效应中的作用,为设计更有效、更合理的抗肿瘤靶向药物提供理论依据。The surface of nano preparation modified by carbohydrate compounds can achieve tumor targeted drug delivery and enhance the anti-tumor effect of drugs.In this paper,tumor targeting effects of nanocentric drugs designed with different types of sugar compounds as transport substrates are reviewed.Meanwhile,based on Warburing effect and glucose transport process,the anti-tumor mechanism of glycolide-modified nanodrugs is studied.The glucose-ligand modified nanomaterials can effectively control or utilize the role of glucose transporters in Warburg effect,providing theoretical basis for the design of more effective and reasonable anti-tumor targeted drugs.

关 键 词：糖类化合物 纳米粒子 肿瘤靶向 葡萄糖转运体 Warburing效应 

分 类 号：R730.5[医药卫生—肿瘤]