稳定期精神分裂症患者血浆细胞因子水平与认知功能的相关研究  

Relationship between plasma cytokine level and cognitive function in patients with stable schizophre・nia

作　　者：冯薇 贾强[3] 谭淑平 于婷[4] 李佳[4] 王志仁[5] 杨甫德[6] 田莉[7] 谭云龙 Feng Wei;Jia Qiang;Tan Shuping;Yu Ting;Li Jia;Wang Zhiren;Yang Fude;Tian Li;Tan Yunlong(Peking University Sixth Hospital,Peking University Institute of Menial Health,Beijing 100191,China;The Fifth Clinical Department,Peking University Huilongguan Clinical Medical School,Beijing Huilongguan Hospital,Beijing 100096,China;The Sixth Clinical Department,Peking University Huilongguan Clinical Medical School,Beijing Huilongguan Hospital,Beijing 100096,China;Research Centre,Peking University Huilongguan Clinical Medical School,Beijing Huilongguan Hospital,Beijing 100096,China;Science and Technology Department,Peking University Huilongguan Clinical Medical School,Beijing Huilongguan Hospital,Beijing 100096,China;Hospital Office Department,Peking University Huilongguan Clinical Medical School,Beijing Huilongguan Hospital,Beijing 100096,China;Neuroscience Centre,University of Helsinki,Helsinki 0001496,Finland)

机构地区：[1]北京大学第六医院,北京大学精神卫生研究所,100191 [2]北京大学回龙观临床医学院,北京回龙观医院临床五科,100096 [3]北京大学回龙观临床医学院,北京回龙观医院临床六科,100096 [4]北京大学回龙观临床医学院,北京回龙观医院研究中心,100096 [5]北京大学回龙观临床医学院,北京回龙观医院科技处,100096 [6]北京大学回龙观临床医学院,北京回龙观医院院办公室,100096 [7]赫尔辛基大学神经科学中心,FIN-0001496

出　　处：《中华行为医学与脑科学杂志》2019年第11期983-987,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：北京市医管局临床技术创新项目(XMLX201513);国家自然科学基金国际(地区)合作项目(中芬)(81461130016)。

摘　　要：目的探讨稳定期精神分裂症患者血浆细胞因子水平与认知功能之间的关系,探索细胞因子在患者认知损伤发生机制中可能的作用。方法共纳入符合DSM-IV精神分裂症诊断标准的稳定期患者75例(研究组),健康对照40例(对照组)。采用酶联免疫(Elisa)法检测所有研究对象的血浆促炎因子IL・10、IL・8、TNF・a,抗炎因子IL-10浓度;使用MATRICS认知评估系统(MATRICS consensus cognitive battery,MCCB)评定认知功能。比较患者组与对照组血浆细胞因子浓度差异,并分析其与患者认知功能的关系。结果(1)研究组与对照组相比,血浆IL-8[2.80(2.13)pg/ml,0.23(0.80)pg/ml],TNF-a[l.16(0.47)pg/ml,0.67(0.15)pg/ml]的差异有统计学意义(PvO.01);(2)研究组血浆细胞因子与认知功能进行偏相关分析,TNF-a与注意/警觉维度之间呈负相关(r=-0.29,P=0.03)o结论稳定期精神分裂症患者存在部分细胞因子的异常,其中TNF-a的激活程度与患者注意警觉维度之间存在一定的相关性。Objective To explore the relationship between plasma cytokine level and cognitive function in patients with stable schizophrenia and explore the possible role of cytokine in the occurrence mechanism of cognitive impairment in them.Methods A total of 75 stable patients who met the mental dis・order diagnostic criteria of DSM-IV(patient group)and 40 healthy people(control group)were included in the essay.The method of enzymelinked immunosorbent assay(ELISA)were used to detected the concentra tions of plasma proinflammatory cytokines IL・10,IL-8,TNF-a and IFN--y as well as the anti-inflammatory cytokines IL-10 in all research objects.The MATRICS Consensus Cognitive Battery(MCCB)was used to assess the cognitive function of patients.The relationship between plasma cytokines and cognitive function of patients were analyzed when the differences of the plasma cytokines concentrations were compared between the patient group and the control group.Results(1)Compared with the control group,plasma IL-8(2.80(2.13)pg/ml vs 0.23(0.80)pg/ml),TNF-a(1.16(0.47)pg/ml vs 0.67(0.15)pg/ml)in the patient group showed statistically significant difference(P<0.01).(2)In the partial correlation analysis of plasma cytokines and cognitive functions in patients,TNF-a was negatively correlated with the attention/vigilance dimensions(r=-0.29,P=0.03).Conclusion Stable schizophrenia patients have some problems with cyto・kine level.There is a correlation between TNF-a level and attention/vigilance dimensions.What's more,cytokine level immunological abnormalities may play some role in the development of cognitive impairment occur・rence in patients.

关 键 词：稳定期精神分裂症 细胞因子 认知功能 

分 类 号：R74[医药卫生—神经病学与精神病学]