普萘洛尔联合32P敷贴治疗儿童脉管畸形疗效分析  

Efficacy of Propranolol Combined with 32P Application in the Treatment of Vascular Diseases in Children

作　　者：任娟[1] 葛维媛[2] 成超[1] 

机构地区：[1]山东省青岛市市立医院核医学科,山东青岛266000 [2]山东省青岛市市立医院检验科采血处,山东青岛266000

出　　处：《中国美容医学》2020年第1期29-32,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:研究普萘洛尔联合磷32(32P)敷贴治疗儿童脉管畸形的临床效果。方法:选取2016年1月-2018年1月笔者医院收治的86例脉管畸形患儿,按照治疗方法不同分为单纯组与联合组,每组43例。单纯组:使用普萘洛尔治疗;联合组:使用普萘洛尔联合32P敷贴治疗,连续治疗3个月,并对患者进行为期1年的随访。治疗期间密切观察患儿血压、心率、睡眠及病变部位的变化情况,并在治疗结束后对患儿家属进行护理指导。观察两组患儿的治疗效果、不良反应发生率及治疗满意度。结果:单纯性血管瘤的治疗效果高于静脉畸形与混合型血管瘤。静脉畸形与混合型血管瘤疗效比较差异无统计学意义(P>0.05);联合组的疗效优于单纯组(P<0.05),联合组的治疗总有效率亦显著高于单纯组(P<0.05);联合组患儿治疗后湿性皮炎、干性皮炎及色素脱失的发生率均高于单纯组,组间比较差异无统计学意义(P>0.05);联合组患儿色素沉着的发生率低于单纯组,组间比较差异也无统计学意义(P>0.05);联合组患儿的治疗满意度显著高于单纯组(P<0.05)。结论:普萘洛尔联合32P敷贴治疗儿童脉管畸形效果明显,可显著提高有效率,且患儿家属对治疗满意,为临床治疗与护理提供了依据。Objective To study the clinical effect of propranolol combined with Phosphorus 32 (32P) application in the treatment of children’s hemangioma.Methods 86 cases of cutaneous hemangioma in our hospital from January 2016 to January 2018 were selected.According to the treatment method,they were divided into simple group and combined group,43 cases each.The simple group was treated with propranolol,and the combined group was treated with propranolol combined with 32P dressing for 3 months,the patients were followed up for one year.During the treatment,the changes of blood pressure,heart rate,sleep and the lesion site of hemangioma were closely observed,and the family members of the children were given nursing guidance after the treatment.The therapeutic effect,incidence of adverse reactions and treatment satisfaction of children with hemangioma were observed and compared between the two groups.Results The treatment effect of simple hemangioma is higher than that of Venous malformations and mixed hemangioma.There was no significant difference in the therapeutic effect between Venous malformations and mixed hemangioma (P>0.05).The therapeutic effect of combined group was better than that of simple group (P<0.05).The total effective rate of combined group was also significantly higher than that of simple group (P<0.05).After treatment,children in combined group had wet dermatitis,dry dermatitis and depigmentation.The incidence of pigmentation in the combined group was lower than that in the simple group,and there was no significant difference between the two groups (P>0.05).The treatment satisfaction in the combined group was significantly higher than that in the simple group (P<0.05).Conclusion Propranolol combined with 32P dressing in the treatment of children’s hemangioma has obvious effect,the effective rate is significantly improved,and the treatment satisfaction of children’s family members is better,it provides a basis for clinical treatment and nursing.

关 键 词：血管瘤 普萘洛尔 32P敷贴 静脉畸形 混合型血管瘤 

分 类 号：R732.2[医药卫生—肿瘤]