30例T2N0M0期非小细胞肺癌立体定向放射治疗临床疗效分析  

Clinical outcomes of stereotactic body radiation therapy for T2N0M0 non-small cell lung cancer

作　　者：朱瑶瑶 杨双燕 杨文艳 林清认 邵凯南 徐清华[2] 刘辉[2] 许亚萍[1] Zhu Yaoyao;Yang Shuangyan;Yang Wenyan;Lin Qingren;Shao Kainan;Xu Qinghua;Liu hui;Xu Yaping(First Clinical Medical School,Wenzhou Medical University,Wenzhou 325035,China;Department of Radiation Oncology,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200433,China;Department of Radiation Oncology,Cancer Hospital of University of Chinese Academy of Sciences,Hangzhou 310022,China)

机构地区：[1]温州医科大学第一临床医学院,325035 [2]同济大学附属上海市肺科医院肿瘤放疗科,上海200433 [3]中国科学院大学附属肿瘤医院放疗科,杭州310022

出　　处：《中华放射医学与防护杂志》2019年第12期904-909,共6页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的探讨利用体部立体定向放射治疗(SBRT)技术治疗T2N0M0期非小细胞肺癌(NSCLC)的临床疗效及不良反应。方法回顾性分析接受SBRT治疗的30例不适合手术T2N0M0期NSCLC患者的临床资料,探讨其总生存率、无进展生存率、肿瘤特异性生存率和不良反应。结果中位随访时间18.4个月。1、2、3年的总生存率分别为92.2%、92.2%和80.6%,肿瘤特异性生存率分别为95.7%、95.7%和83.7%,无进展生存率分别为70.2%、54.1%和40.6%,局部控制率分别为100%、94.4%和94.4%,区域控制率分别为84.2%、72.1%和54.1%,远处控制率分别为84.6%、72.4%和64.3%。20例患者出现1级放疗相关不良反应;5例患者出现≥2级的放射性肺炎;1例患者出现4级放射性肺炎。结论SBRT治疗对不适合手术的T2N0M0期NSCLC患者有较好的疗效,不良反应可耐受。Objective To investigate the clinical efficacy and adverse effects of stereotactic body radiotherapy(SBRT)in the treatment of T2N0M0 non-small cell lung cancer(NSCLC)patients.Methods By retrospectively analyzing the clinical data of 30 inoperable patients with stage T2N0M0 NSCLC treated by SBRT,the overall survival,progression-free survival,cancer-specific survival and adverse effects were determined.Results The median follow-up was 18.4 months.The 1-,2-,and 3-year overall survival rates were 92.2%,92.2%and 80.6%,respectively.The corresponding cause-specific survivals were 95.7%,95.7%and 83.7%.The progression-free survivals were 70.2%,54.1%and 40.6%.The local control rates were 100%,94.4%,and 94.4%.The regional controls were 84.2%,72.1%,and 54.1%;and distant controls were 84.6%,72.4%and 64.3%,respectively.Twenty patients(66.7%)developed symptoms of grade 1 radiation-related toxicities:dyspnea,chest pain,fatigue,cough,esophagitis,or pneumonia.Among these,5 patients suffered grade≥2 radiation pneumonitis,and one patient experienced grade 4 radiation pneumonitis.Conclusions SBRT was efficient and safe for patients with inoperable T2N0M0 NSCLC,imposing tolerable toxicities.

关 键 词：立体定向放射治疗 非小细胞肺癌 总生存 无进展生存 肿瘤特异性生存 

分 类 号：R73[医药卫生—肿瘤]