A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides  

作　　者：ZHANG JieD WANG Chuan-XiD SONG Xiao-Jun LI Shuang ZHAO Huan CHEN Guo-Dong HU Dan GAO Hao YAO Xin-Sheng 

机构地区：[1]College of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China [2]Institute of Traditional Chinese Medicine&Natural Products,College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,Jinan University,Guangzhou 510632,China

出　　处：《Chinese Journal of Natural Medicines》2019年第12期906-911,共6页中国天然药物（英文版）

基　　金：supported by grants from the National Key Research and Development Program of China(Nos.2018YFA0903200 and 2018YFA0903201);the National Natural Science Foundation of China(No.31761143016);Chang Jiang Scholars Program(GAO Hao,2017)from the Ministry of Education of China;National High-level Personnel of Special Support Program(No.2017RA2259);Guangdong Special Support Program(No.2016TX03R280);Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine(No.QNRC2-B06);Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(GAO Hao,2014);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Y036);K.C.Wong Education Foundation(GAO Hao,2016)

摘　　要：A pair of new tirucallane triterpenoid epimers,picraquassins M and N(1 and 2),were isolated from the stems of Picrasma quassioides(D.Don)Benn.Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses.In addition,their ACh E inhibitory activity,cytotoxicity against five human tumour cell lines(SW480,MCF-7,HepG2,Hela,and PANC-1),and antimicrobial activity against two bacteria(Staphylococcus.aureus 209 P and Escherichia coli ATCC0111)and two fungi(Candida albicans FIM709 and Aspergillus niger R330)were evaluated.A pair of new tirucallane triterpenoid epimers, picraquassins M and N(1 and 2), were isolated from the stems of Picrasma quassioides(D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their ACh E inhibitory activity, cytotoxicity against five human tumour cell lines(SW480, MCF-7, HepG2, Hela, and PANC-1), and antimicrobial activity against two bacteria(Staphylococcus. aureus 209 P and Escherichia coli ATCC0111) and two fungi(Candida albicans FIM709 and Aspergillus niger R330) were evaluated.

关 键 词：Tirucallane triterpenoid EPIMERS Picrasma quassioides AChE inhibitory activity CYTOTOXICITY Antimicrobial activity 

分 类 号：R284[医药卫生—中药学]