Chemical constituents from Vernonia bockiana  

作　　者：DONG Shi-Hui WU Yan YUE Jian-Min 

机构地区：[1]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [2]State Key Laboratory of Applied Organic Chemistry,College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000,China

出　　处：《Chinese Journal of Natural Medicines》2019年第12期924-927,共4页中国天然药物（英文版）

基　　金：supported by the Drug Innovation Major Project of China(No.2018ZX09711001-001-005);the Biological Resources Programme(No.CAS KFJ-BRP-008)

摘　　要：A new sesquiterpenoid and two pregnane steroids,named vernobockolide C(1)and vernobockones A and B(2 and 3),respevtively,along with a known sesquiterpenoid,7,10-epoxy-11-hydroxy-bisabol-2-en-15-al,were isolated from the aerial part of Vernonia bockiana.Their structures were elucidated on the basis of extensive spectroscopic data analysis,especially 2 D NMR(HSQC,HMBC,and ROESY).This study further expands the chemical space of this underexplored species.A new sesquiterpenoid and two pregnane steroids, named vernobockolide C(1) and vernobockones A and B(2 and 3), respevtively, along with a known sesquiterpenoid, 7, 10-epoxy-11-hydroxy-bisabol-2-en-15-al, were isolated from the aerial part of Vernonia bockiana. Their structures were elucidated on the basis of extensive spectroscopic data analysis, especially 2 D NMR(HSQC, HMBC, and ROESY). This study further expands the chemical space of this underexplored species.

关 键 词：Vernonia bockiana SESQUITERPENOID STEROID 

分 类 号：R284[医药卫生—中药学]