Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces  

作　　者：WANG Lei WANG Li ZHOU Zhi WANG Yong-Jiang HUANG Jian-Ping MA Ya-Tuan LIU Yang HUANG Sheng-Xiong 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,and CAS Center for Excellence in Molecular Plant Sciences,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [2]College of Chemistry and Pharmacy,Northwest Agriculture and Forestry University,Yangling 712100,China [3]Research Center,Chengdu Medical College,Chengdu 610500,China [4]Savaid Medical School,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Journal of Natural Medicines》2019年第12期982-987,共6页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.U1702285 and 81522044);Natural Science Foundation of Yunnan Province(No.2016FA003);the State key laboratory of phytochemistry and plant resource in west China(No.P2018-KF03);Key Research Program of Frontier Sciences and the Strategic Priority Research Program,CAS(Nos.QYZDB-SSW-SMC051 and XDB27020205)

摘　　要：Cangumycins A-F(1–6), six new angucyclinone analogues, together with two known ones(7 and 8), were isolated from the fermentation broth of a soil-derived Streptomyces sp. KIB-M10. Structures of these compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Among them, cangumycins E(5) and F(6) share a C-ring cleaved backbone, and cangumycins B(2) and E(5) exhibit potent immunosuppressive activity(IC50 8.1 and 2.7 μmol·L^-1, respectively) against human T cell proliferation at a non-cytotoxic concentration.Cangumycins A-F(1–6), six new angucyclinone analogues, together with two known ones(7 and 8), were isolated from the fermentation broth of a soil-derived Streptomyces sp. KIB-M10. Structures of these compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Among them, cangumycins E(5) and F(6) share a C-ring cleaved backbone, and cangumycins B(2) and E(5) exhibit potent immunosuppressive activity(IC50 8.1 and 2.7 μmol·L-1, respectively) against human T cell proliferation at a non-cytotoxic concentration.

关 键 词：STREPTOMYCES Angucyclinones Benz[a]anthracenes Natural products Immunosuppressive activity 

分 类 号：R284[医药卫生—中药学]