XELOX方案联合肝动脉化疗栓塞治疗胃癌伴肝转移的有效性与安全性  

Efficacy and safety of XELOX regimen combined with transcatheter arterial chemoembolization in the treatment of gastric cancer with liver metastasis

作　　者：黄和[1] 陈其余[2] 周磊[1] 姚志超[1] 王奕庚 倪仲琳[1] Huang He;Chen Qiyu;Zhou Lei;Yao Zhichao;Wang Yigeng;Ni Zhonglin(Department of General Surgery,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 325027,China;Operation Room,the Second,Affiliated Hospital of Wenzhou Medical University,Wenzhou 325027 China)

机构地区：[1]温州医科大学附属第二医院普外科,浙江省325027 [2]温州医科大学附属第二医院手术室,浙江省325027

出　　处：《中华普通外科杂志》2019年第12期1048-1051,共4页Chinese Journal of General Surgery

基　　金：温州市科技计划资助项目(Y20160424)。

摘　　要：目的评价XELOX方案联合肝动脉化疗栓塞治疗胃癌伴肝转移的有效性与安全性。方法将50例胃癌伴肝转移患者随机分成2组,试验组25例先行XELOX方案化疗:希罗达片1000 mg/m^2口服,2次/山第1~14天;奥沙利钳130 mg/m^2,静脉滴注,第1天。1周后行肝动脉化疗栓塞,4周为1个周期。对照组25例,按XELOX方案化疗,3周为1个周期。所有病例每治疗2个周期评价1次疗效和毒副反应。结果试验组总有效率为56%,肿瘤控制率为80%,Kamofsky评分提高率为60%,有10例获得了手术的机会;对照组总有效率为32%,肿瘤控制率为52%,Kamofsky评分提高率为48%,有6例获得了手术的机会。两组的总有效率、肿瘤控制率、手术治疗率及卡式评分提高率相比差异均有统计学意义(均P<0.05)o试验组患者的中位总生存时间为12.5个月,对照组为10.5个月,两组相比差异有统计学意义(PV0.05)。试验组的毒副反应较对照组无明显增加。结论XELOX方案联合肝动脉化疗栓塞治疗胃癌伴肝转移是有效安全的。Objective To evaluate the efficacy and safety of XELOX regimen combined with hepatic artery chemoembolization in the treatment of gastric cancer with liver metastasis.Methods 50 cases of gastric cancer with liver metastasis were randomly divided into two groups,the experimental group(25 cases)received chemotherapy regimen of XELOX first:Xeloda tablets 1000 mg/m^2,orally,twice a day,daysl—14;Oxaliplatin 130 mg/m^2,intravenous drip,day 1.Hepatic artery chemoembolization was performed one a week later,and a cycle consists of 4 weeks.The control group(25 cases)received chemotherapy regimen of XELOX,3 weeks as a cycle.All patients were evaluated for efficacy and toxicity every 2 cycles.Results In the experimental group,the overall response rate was 56%,the tumor control rate was 80%,the increase rate of Kamofsky was 60%,and 10 patients got chance of tumor resection.In the control group,the overall response rate was 32%,the tumor control rate was 52%,the increase rate of Kamofsky was 48%,and 6 patients got chance of operation.The overall response rate,tumor control rate,surgical treatment rate and the increase rate of Kamofsky in the experimental group were significantly different from those in the control group(P<0.05).The median total survival time was 12.5 months in the experimental group and 10.5 months in the control group(P<0.05).There was no significant difference in toxicity and side effects between the two groups.Conclusion XELOX regimen combined with hepatic artery chemoembolization is effective and safe in the treatment of gastric cancer with liver metastasis.

关 键 词：胃肿瘤 栓塞 治疗性 肿瘤转移 联合化疗方案 

分 类 号：R73[医药卫生—肿瘤]