超声显像特征与乳腺癌组织中HER-2表达的关系研究  

Relationship between Ultrasonographic Features of Breast Cancer and Expression of HER-2 in Breast Cancer

作　　者：叶芬 王丽萍[2] YE Fen;WANG Liping(Concord Honghu Hospital,Honghu,433200)

机构地区：[1]湖北省洪湖市协和洪湖医院,433200 [2]华中科技大学同济医学院附属协和医院,430022

出　　处：《实用癌症杂志》2020年第1期50-52,共3页The Practical Journal of Cancer

基　　金：湖北省自然科学基金(编号:2016CFB426)

摘　　要：目的分析乳腺癌中超声显像特征与乳腺癌组织HER-2表达的关系。方法回顾性分析女性乳腺癌患者共84例,收集其术前检查的超声显像特征,并收集其病理结果中免疫组化法检测的HER-2表达的结果,分析超声显像特征与乳腺癌组织HER-2表达的关系。结果 84例女性乳腺癌患者中,其中HER-2表达为阴性的共21例,弱阳性共26例,阳性29例,强阳性的8例,其中低表达56. 0%,高表达44%,超声特征中乳腺癌的HER-2表达水平与肿瘤大小、内部钙化呈显著相关性(P <0. 05),而乳腺癌的HER-2表达水平与边缘情况、肿瘤形状、肿瘤纵横比、内部回声、后方回声衰减和血供分级没有显著的相关性(P> 0. 05)。结论超声特征中乳腺癌的HER-2表达水平与肿瘤大小和内部钙化具有密切的关系。Objective To analyze the relationship between the features of ultrasound imaging and the expression of HER-2 in breast cancer. Methods A total of 84 female breast cancer patients were retrospectively analyzed. The ultrasonographic features of preoperative examination were collected and the pathological results were collected by immunohistochemistry. The results of HER-2 expression were analyzed for the relationship between ultrasound imaging characteristics and HER-2 expression in breast cancer tissues. Results In the 84 female breast cancer patients,21 were negative for HER-2 expression,26 were weakly positive,29 were positive,and 8 were strongly positive,of which 56. 0% were low expression,and high expression was 44%. The HER-2 expression level of breast cancer was significantly correlated with tumor size and internal calcification( P < 0. 05),while HER-2 expression and margin of breast cancer,tumor shape,tumor cross-section ratio,internal echo,posterior echo attenuation,and blood supply grading had no significant correlation( P > 0. 05). Conclusion The HER-2 expression level of breast cancer in ultrasound features is closely related to tumor size and internal calcification.

关 键 词：乳腺癌 超声 特征 人表皮生长因子受体2 关系 

分 类 号：R737.9[医药卫生—肿瘤]