GABAB受体在治疗脑缺血后焦虑的作用  

The role of GABAB receptors in the treatment of postischemic anxiety

作　　者：张娟[1] 殷博凯 郭艳芹 何治[1] ZHANG Juan;YIN Bokai;GUO Yanqin;HE Zhi(Medical College of Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学医学院

出　　处：《生命的化学》2019年第6期1127-1132,共6页Chemistry of Life

基　　金：国家自然科学基金面上项目(81371318)

摘　　要：氨基丁酸(γ-aminobutyric acid,GABA)是哺乳动物中枢神经系统中的一种抑制性神经递质,它主要通过GABAA、GABAB和GABAC三种不同的受体介导其作用。GABAA和GABAC为离子型受体,而GABAB为G蛋白偶联受体。大量研究表明,GABAB受体与脑缺血后焦虑密切相关。本文对GABAB受体、GABAB受体与脑缺血后神经功能的关系、脑缺血后焦虑、GABAB受体与脑缺血后焦虑的关系及其相关治疗作一综述。aminobutyric acid(GABA)is an inhibitory neurotransmitter in the mammalian central nervous system.GABAA,GABAB and GABAC are mainly used to mediate its functions.GABAA and GABAC are ionic receptors,while GABAB is G protein-coupled receptor.A large number of studies have shown that GABAB receptors are closely related to anxiety after cerebral ischemia.This article reviews the GABAB receptor,the relationship between GABAB receptor and neural function after cerebral ischemia,anxiety after cerebral ischemia,the relationship between GABAB receptor and anxiety after cerebral ischemia and the related treatment.

关 键 词：脑缺血 焦虑 GABAB受体 

分 类 号：R74[医药卫生—神经病学与精神病学]