丙型肝炎感染导致的肝硬化向肝细胞癌进展的分子机制  

Molecular mechanisms driving progression of liver cirrhosis towards hepatocellular carcinoma in hepatitis C infections

作　　者：于立娟 徐建玲 张媛英 翟静 YU Lijuan;XU Jianling;ZHANG Yuanying;ZHAI Jing(Department of Basic Medicine,Shandong First Medical University&Shandong Academy of Medical Sciences,Taian 271000,China)

机构地区：[1]山东第一医科大学(山东省医学科学院)基础医学院生物化学教研室

出　　处：《生命的化学》2019年第6期1211-1217,共7页Chemistry of Life

基　　金：山东省卫生科技发展计划项目(2017ws256);山东省中医药科技发展计划项目(2015-157);山东省高等学校科技计划项目(J15LE11);泰安市科技发展计划项目(2015NS2062)

摘　　要：几乎所有的原发性肝癌(hepatocellular carcinoma,HCC)患者都患有肝硬化。肝硬化常阻碍对HCC的有效治疗。本文从遗传学和表观遗传学的角度总结了近年来有关肝硬化分子机制及进展为肝癌的研究进展。约70%的肝癌患者有乙型肝炎病毒(hepatitis B virus,HBV)和/或丙型肝炎病毒(hepatitis C virus,HCV)感染。鉴于HCV感染缺乏疫苗预防,在我国发病率逐年提高,本文将重点阐述与HCV相关的HCC。某些基因和表观遗传因子如microRNAs在肝硬化及进展为肝癌中发挥作用,并且HCV编码的蛋白质似乎参与了肝癌的发生。因此,有必要对免疫检查点和激酶抑制剂的分子靶点等进行进一步的研究,阐明肝硬化进展为肝癌相关的机制。Almost all patients with hepatocellular carcinoma(HCC),a major type of primary liver cancer,also have liver cirrhosis,the severity of which hampers effective treatment for HCC despite recent progress in the efficacy of anticancer drugs for advanced stages of HCC.Here,we review recent knowledge concerning the molecular mechanisms of liver cirrhosis and its progression to HCC from genetic and epigenomic points of view.Because^70%of patients with HCC have hepatitis B virus(HBV)and/or hepatitis C virus(HCV)infection,we focused on HCV-associated HCC.The literature suggests that genetic and epigenetic factors,such as microRNAs,play a role in liver cirrhosis and its progression to HCC,and that HBV-and HCV-encoded proteins appear to be involved in hepatocarcinogenesis.Further studies are needed to elucidate the mechanisms,including immune checkpoints and molecular targets of kinase inhibitors,associated with liver cirrhosis and its progression to HCC.

关 键 词：肝硬化 丙型肝炎 肝癌 

分 类 号：R73[医药卫生—肿瘤]