舒肝宁注射液联合还原型谷胱甘肽治疗药物性肝损伤的临床研究  

Clinical Study of Shuganning Injection Combined with Reduced Glutathione for Injection in the Treatment of Drug-induced Liver Injury

作　　者：孙玉明[1] 张帮杰[2] SUN Yu-ming;ZHANG Bang-jie(Department of Gastroenterology,People's Hospital of Xinxiang County,Xinxiang Henan,453700,China;不详)

机构地区：[1]新乡县人民医院消化内科,河南新乡453700 [2]新乡医学院第三附属医院消化内科

出　　处：《中西医结合肝病杂志》2019年第6期516-519,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨舒肝宁注射液联合还原型谷胱甘肽治疗药物性肝损伤的临床疗效及安全性。方法:选取新乡县人民医院及新乡医学院第三附属医院2017年1月至2018年12月收治的药物性肝损伤患者,应用新版RUCAM量表评定积分,分值≥3分者入选,共入选80例患者。随机分为对照组和观察组,各40例。两组患者均停用可疑诱导肝损伤的药物,对照组患者采用注射用还原型谷胱甘肽1.2 g加入5%葡萄糖注射液250 ml中静脉滴注,1次/d;观察组患者在对照组治疗的基础上加用舒肝宁注射液10 ml加入10%葡萄糖注射液250 ml中静脉滴注,1次/d。两组患者均连续治疗4周。观察两组患者临床疗效;比较两组患者治疗前后肝功能ALT、ALP、TBil等指标变化;全程观察两组患者治疗药物的不良反应。结果:治疗4周末,对照组和观察组患者的总有效率分别为75.0%、92.5%,两组比较,差异有统计学意义(P<0.05)。治疗4周末,两组患者ALT、ALP、TBil指标均较治疗前显著下降,差异有统计学意义(P<0.05),观察组患者各项指标较对照组下降更明显,差异有统计学意义(P<0.05)。治疗过程中,两组患者均没有发生不良反应。结论:舒肝宁注射液联合还原型谷胱甘肽治疗药物性肝损伤疗效显著,患者无明显不良反应,安全性好,具有一定的临床推广应用价值。Objective:To investigate the clinical efficacy and safety of ShuGanning injection combined with reduced glutathi for injection in the treatment of drug-induced liver injury.Methods:Selecting the patients with drug-induced liver injury admitted to People’s Hospital of Xinxiang County and the Third Affiliated Hospital of Xinxiang Medical College from January 2017 to December 2018, the new version of the RUCAM scale was used to assess the score. The score was more than 3 points into the group. A total of 80 patients were enrolled. They were randomly divided into control group(40 cases) and observation group(40 cases).Two groups of patients were discontinued drugs suspected of inducing liver injury. The control group was intravenous injection with Reduced Glutathione for Injection 1.2 g into 5% Glucose Injection 250 ml, once daily. The observation group was given Shuganning injection 10 ml into 10% glucose injection 250 ml intravenous injection on the basis of the control group, once daily. Two groups of patients were treated for 4 weeks. The clinical efficacy of the two groups was observed, the changes of liver function ALT, ALP and TBil were compared between the two groups before and after treatment, the whole course of treatment observed adverse reactions of two groups of patients. Results:At the end of the 4 th week treatment,the total effective rates of the control group and the observation group were 75.0% and 92.5%respectively.The observation group was significantly higher than the control group, the difference between the two groups was statistically significant(P<0.05). At the end of the 4 th week treatment, The indexes of ALT, ALP and TBil in the two groups were significantly lower than before was treatment, the difference was statistically significant(P<0.05), the observation group decreased more significantly than the control group,the difference was statistically significant(P<0.05).In the course of treatment, no adverse reactions occurred in the two groups. Conclusion:Shuganning injection combined wit

关 键 词：药物性肝损伤 新版RUCAM量表 舒肝宁注射液 还原型谷胱甘肽 不良反应 

分 类 号：R575[医药卫生—消化系统]