谷氨酸受体拮抗剂联合卡巴拉汀治疗阿尔茨海默病患者的临床疗效  

Clinical efficacy of glutamate receptor antagonist combined with carbaratin in treatment of Alzheimer S disease

作　　者：皇甫乐煜 HUANGFU Le-yu(Department of Neurology,the Nanyang Second General Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市第二人民医院神经内科,河南南阳473000

出　　处：《医药论坛杂志》2019年第12期95-97,共3页Journal of Medical Forum

摘　　要：目的探究阿尔茨海默病患者采用谷氨酸受体拮抗剂、卡巴拉汀联合治疗的效果。方法选取南阳市第二人民医院2017年1月-2018年12月收治的阿尔茨海默病患者患者102例,根据治疗方案不同分为观察组(n=51)和对照组(n=51),对照组采用谷氨酸受体拮抗剂即美金刚治疗,在此基础上观察组加用卡巴拉汀治疗,评估2组临床疗效,治疗前后认知功能(MMSE评分)、日常生活能力(ADL评分)、痴呆病理行为(BEHAVEAD评分)及不良反应。结果治疗24周后,观察组总有效率90.20%较对照组72.55%高(P<0.05);观察组MMSE、ADL评分高于对照组,BEHAVE-AD评分低于对照组(P<0.05);观察组不良反应发生率13.73%与对照组9.80%相比无显著差异(P>0.05)。结论谷氨酸受体拮抗剂联合卡巴拉汀治疗阿尔茨海默病,疗效确切,可有效改善患者认知功能,减轻病理行为障碍,提升日常生活能力,且安全性高。Objective To explore the effect of combined therapy of glutamate receptor antagonist and kabalatin in patients with Alzheimers disease.Methods From January 2017 to December 2018,102 patients with Alzheimer^disease admitted to our hospital were divided into observation group(n=51)and control group(n=51)according to different treatment schemes.The control group was treated with glutamate receptor antagonist Memantine.While the observation group was treated with Kabalatin on the basis of the control group,and the clinical treatment,effectiveness,ADL score,pathological behavior of dementia(BEHAVE-AD score)and adverse reactions of the two groups before and after treatment was evaluated.Results After 24 weeks of treatment,the total effective rate of the observation group was 90.20% higher than 72.55%of the control group(P<0.05);the ADL score of the observation group wa3 higher than that of the control group,and the BEHAVE-AD score was lower than that of the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the observation group and the control group(13.73%vs.9.80%)(P>0.05).Conclusion Glutamate receptor antagonist combined with kabalatin is effective in the treatment of Alzheimer^disease.It can improve patientsHaily living ability,promote pathological behavior disorders and also has high safety.

关 键 词：阿尔茨海默病 谷氨酸受体拮抗剂 卡巴拉汀 日常生活能力 不良反应 痴呆病理行为 美金刚 

分 类 号：R749.16[医药卫生—神经病学与精神病学]